Suppressive effect of lipid A partial structures on lipopolysaccharide or lipid A-induced release of interleukin 1 by human monocytes.
Suppressive effect of lipid A partial structures on lipopolysaccharide or lipid A-induced release of interleukin 1 by human monocytes.
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脂质A部分结构对脂多糖或脂质A诱导的人单核细胞释放白细胞介素1的抑制作用。
DOI：
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发表时间：
1990
期刊：
影响因子：
--
通讯作者：
A. Ulmer
中科院分区：
文献类型：
--
作者：
M. Wang;W. Feist;H. Herzbeck;H. Brade;S. Kusumoto;E. Rietschel;H. Flad;A. Ulmer
Experiments were designed to investigate the significance of lipid A partial structures, precursor Ia (compound 406), and lipid X (compound 401) to serve as antagonists of interleukin 1 (IL-1) release from human mononuclear cells and monocytes induced by lipopolysaccharide (LPS, endotoxin) of Salmonella abortus equi or synthetic Escherichia coli lipid A (compound 506). A definite inhibition mediated by lipid A partial structures on IL-1 release induced by LPS or lipid A was found in repeated experiments. The inhibitory effect was exerted not only on IL-1 release, but also on IL-1 peptide synthesis at the intracellular level. The results also show that lipid A partial structures have suppressive effects even when added 1-4 h after LPS or lipid A. We conclude from these results that lipid A partial structures (precursor Ia and lipid X) have potent immunomodulatory effects on LPS- and lipid A-induced IL-1 release and may become useful reagents to study the mechanism of interaction of LPS and lipid A with cells of the immune system.
影响因子：
4.4
作者：
M. Lei;D. Morrison
通讯作者：
M. Lei;D. Morrison