Diverse effects of phytoestrogens on the reproductive performance: cow as a model.

Diverse effects of phytoestrogens on the reproductive performance: cow as a model.
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DOI:
10.1155/2013/650984
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发表时间:
2013
影响因子:
2.8
通讯作者:
Skarżyński DJ
Skarżyński DJ
中科院分区:
医学4区
文献类型:
--
作者:
Wocławek-Potocka I;Mannelli C;Boruszewska D;Kowalczyk-Zieba I;Waśniewski T;Skarżyński DJ

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植物雌激素是一种来源于植物的多酚类化合物,在人类和动物的饮食中越来越常见。在大多数情况下,这些化学物质的效力远不如内源性雌激素,但通过类似的作用机制发挥其生物学作用。人类和反刍动物接触植物雌激素的最常见来源是大豆衍生食品,这些食品富含大豆黄酮、染料木素和大豆苷元,在消化道中被代谢为更有效的代谢物-对乙基苯酚和雌马酚。植物雌激素最近引起了相当大的兴趣,因为越来越多的信息表明它们对人类和动物生殖的不利影响,越来越多的人用植物来源的蛋白质替代动物蛋白质。最后,由于1995年欧洲绝对禁止将骨粉用于动物饲料,大豆成为动物饲料中蛋白质的主要来源。本文综述了大豆源性植物雌激素的暴露如何对成年女性的生殖能力产生不利影响。
Phytoestrogens, polyphenolic compounds derived from plants, are more and more common constituents of human and animal diets. In most of the cases, these chemicals are much less potent than endogenous estrogens but exert their biological effects via similar mechanisms of action. The most common source of phytoestrogen exposure to humans as well as ruminants is soybean-derived foods that are rich in the isoflavones genistein and daidzein being metabolized in the digestive tract to even more potent metabolites—para-ethyl-phenol and equol. Phytoestrogens have recently come into considerable interest due to the increasing information on their adverse effects in human and animal reproduction, increasing the number of people substituting animal proteins with plant-derived proteins. Finally, the soybean becomes the main source of protein in animal fodder because of an absolute prohibition of bone meal use for animal feeding in 1995 in Europe. The review describes how exposure of soybean-derived phytoestrogens can have adverse effects on reproductive performance in female adults.
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