Why bacteria matter in animal development and evolution
Why bacteria matter in animal development and evolution
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DOI：
10.1002/bies.200900192
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发表时间：
2010-07-01
期刊：
影响因子：
4
通讯作者：
Bosch, Thomas C. G.
中科院分区：
文献类型：
--
作者：
Fraune, Sebastian;Bosch, Thomas C. G.
虽然由于细菌对人类健康的有害影响而受到广泛研究，但人们越来越认识到，细菌是包括人类在内的无脊椎动物和脊椎动物的重要合作伙伴。后生动物的上皮不仅选择它们的微生物区系；共同进化的微生物联盟使无脊椎动物和脊椎动物都能够扩大食物供应的范围，塑造复杂的免疫系统，并控制病原菌。斑马鱼和老鼠体内的微生物调节肠道上皮的动态平衡。在鱿鱼体内，微生物控制着共生发光器的发育。这些发现指出了细菌在任何后生动物存在中的关键作用，并暗示有益的细菌与宿主的相互作用应被视为发育和进化的组成部分。
While largely studied because of their harmful effects on human health, there is growing appreciation that bacteria are important partners for invertebrates and vertebrates, including man. Epithelia in metazoans do not only select their microbiota; a coevolved consortium of microbes enables both invertebrates and vertebrates to expand the range of diet supply, to shape the complex immune system and to control pathogenic bacteria. Microbes in zebrafish and mice regulate gut epithelial homeostasis. In a squid, microbes control the development of the symbiotic light organ. These discoveries point to a key role for bacteria in any metazoan existence, and imply that beneficial bacteria-host interactions should be considered an integral part of development and evolution.