Multimodality molecular imaging with combined optical and SPECT/PET modalities
Multimodality molecular imaging with combined optical and SPECT/PET modalities
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DOI：
10.2967/jnumed.107.043331
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发表时间：
2008-02-01
影响因子：
9.3
通讯作者：
Achilefu, Samuel
中科院分区：
文献类型：
--
作者：
Culver, Joseph;Akers, Walter;Achilefu, Samuel
今天的医学成像技术被期望提供解剖学、生理学、分子和基因组信息，用于准确的疾病诊断、治疗反应的预测以及高度特异性和敏感性的药物和成像剂的开发。然而，目前用于人类的成像方法都不能提供全面的医学成像。为了利用不同成像方法的优势，多模态成像已成为体内研究的一种有吸引力的策略。除了小动物成像之外，一种不太常用的多模态成像策略是放射学和光学方法的融合。这种不太频繁的使用可能是由于一些误解，技术困难，或缺乏对患者护理中2种方法的好处的认识。这篇简短的评论解决了其中的一些问题，重点是多模态光学和SPECT/PET系统的潜在应用。
Today's medical imaging technologies are expected to furnish anatomic, physiologic, molecular, and genomic information for accurate disease diagnosis, prediction of treatment response, and development of highly specific and sensitive drugs and imaging agents. However, none of the current imaging methods used in humans provides comprehensive medical imaging. To harness the strengths of different imaging methods, multimodality imaging has become an attractive strategy for in vivo studies. Beyond small-animal imaging, a less frequently used multimodality imaging strategy is the fusion of radionuclear and optical methods. This less frequent use is probably attributable to some misconceptions, technical difficulties, or a lack of appreciation for the benefits of the 2 methods in patient care. This minireview addresses some of these concerns, with emphasis on the potential applications of multimodality optical and SPECT/PET systems.