Agaricus blazei (class basidiomycotina) aqueous extract enhances the expression of c-Jun protein in MCF7 cells
Agaricus blazei (class basidiomycotina) aqueous extract enhances the expression of c-Jun protein in MCF7 cells
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DOI：
10.1021/jf011566p
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发表时间：
2002-08-28
影响因子：
6.1
通讯作者：
Maekawa, T
中科院分区：
文献类型：
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作者：
Talorete, TPN;Isoda, H;Maekawa, T
食用菌巴西蘑菇（Agaricus blazei Muril）是一种抗肿瘤和免疫活性化合物的来源，在许多国家被认为是一种健康食品。该担子菌的水提取物（AE）显著增强了人乳腺癌细胞系MCF 7中c-Jun/激活蛋白-1（AP 1）的表达。将细胞与17-β-雌二醇（112）、对壬基苯酚（NP）和AE组合或NP加AE孵育，与未处理的对照相比，细胞增殖分别增加了93%和67%。然而，单独将细胞与提取物一起孵育并不能增强细胞分裂。这表明，在NP和AE的存在下，MCF 7细胞的增殖增强可能是由于AP 1基因调控复合物的参与。这是第一份报告显示在与水性真菌提取物孵育的MCF 7细胞中c-Jun/AP 1表达增强。
The edible mushroom Agaricus blazei Murill is considered a health food in many countries after it was reported to be a source of antitumor and immunoactive compounds. An aqueous extract (AE) from this basidiomycete significantly enhanced the expression of the c-Jun/activator protein-1 (AP1) in the human breast cancer cell line MCF7. Incubating the cells with 17-beta-estradiol (112), p-nonylphenol (NP), and the AE combined, or NP plus the AE, resulted in increased cell proliferation compared to the untreated control by 93 and 67%, respectively. However, incubating the cells with the extract alone did not enhance cell division. It is suggested that the enhanced proliferation of MCF7 cells in the presence of NP and the AE may be due to the involvement of an AP1 gene regulatory complex. This is the first report showing enhanced c-Jun/AP1 expression in MCF7 cells incubated with an aqueous fungal extract.