The roles of hyaluronan/RHAMM/CD44 and their respective interactions along the insidious pathways of fibrosarcoma progression.
The roles of hyaluronan/RHAMM/CD44 and their respective interactions along the insidious pathways of fibrosarcoma progression.
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DOI：
10.1155/2013/929531
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发表时间：
2013
影响因子：
--
通讯作者：
Tzanakakis GN
中科院分区：
文献类型：
--
作者：
Nikitovic D;Kouvidi K;Karamanos NK;Tzanakakis GN
纤维肉瘤是一种罕见的起源于成纤维细胞的恶性间叶质肿瘤。重要的是，纤维肉瘤细胞具有高含量和高周转的细胞外基质（ECM）成分，包括透明质酸（HA）、蛋白聚糖、胶原蛋白、纤连蛋白和层粘连蛋白。 ECM 是围绕并支持组织内细胞的复杂结构。在癌症进展过程中，可以观察到 ECM 组件的结构和机械特性发生显着变化。重要的是，与良性组织相比，恶性肿瘤中的透明质酸沉积通常更高，这预测了某些肿瘤类型的肿瘤进展。此外，活化的基质细胞能够产生富含透明质酸的组织结构，以促进肿瘤生长。 HA 的关键生物学作用源于其与其特定的 CD44 和 RHAMM（HA 介导的运动受体）细胞表面受体的相互作用。 HA 受体下游信号通路反过来调节与肿瘤发生有关的细胞过程。生长因子，包括 PDGF-BB、TGFβ2 和 FGF-2，可增强透明质酸在 ECM 上的沉积，并调节纤维肉瘤细胞中 HA 受体的表达。事实上，FGF-2 通过上调特定 HAS 亚型和透明质酸合成来调节透明质酸的分泌和净透明质酸沉积到纤维肉瘤细胞周围基质，从而调节这些细胞的迁移能力。在本文中，我们讨论了透明质酸/RHAMM/CD44 介导的信号传导在纤维肉瘤进展的隐秘途径中的参与。
Fibrosarcomas are rare malignant mesenchymal tumors originating from fibroblasts. Importantly, fibrosarcoma cells were shown to have a high content and turnover of extracellular matrix (ECM) components including hyaluronan (HA), proteoglycans, collagens, fibronectin, and laminin. ECMs are complicated structures that surround and support cells within tissues. During cancer progression, significant changes can be observed in the structural and mechanical properties of the ECM components. Importantly, hyaluronan deposition is usually higher in malignant tumors as compared to benign tissues, predicting tumor progression in some tumor types. Furthermore, activated stromal cells are able to produce tissue structure rich in hyaluronan in order to promote tumor growth. Key biological roles of HA result from its interactions with its specific CD44 and RHAMM (receptor for HA-mediated motility) cell-surface receptors. HA-receptor downstream signaling pathways regulate in turn cellular processes implicated in tumorigenesis. Growth factors, including PDGF-BB, TGFβ2, and FGF-2, enhanced hyaluronan deposition to ECM and modulated HA-receptor expression in fibrosarcoma cells. Indeed, FGF-2 through upregulation of specific HAS isoforms and hyaluronan synthesis regulated secretion and net hyaluronan deposition to the fibrosarcoma pericellular matrix modulating these cells' migration capability. In this paper we discuss the involvement of hyaluronan/RHAMM/CD44 mediated signaling in the insidious pathways of fibrosarcoma progression.
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影响因子：
11.2
作者：
Benitez A;Yates TJ;Lopez LE;Cerwinka WH;Bakkar A;Lokeshwar VB
通讯作者：
Lokeshwar VB
影响因子：
2.5
作者：
Bourguignon, LYW
通讯作者：
Bourguignon, LYW
影响因子：
4.8
作者：
Bourguignon, LYW;Singleton, PA;Diedrich, F
通讯作者：
Diedrich, F
影响因子：
4.8
作者：
Amara, FM;Entwistle, J;Wright, JA
通讯作者：
Wright, JA
影响因子：
2.2
作者：
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通讯作者：
Forrest, M. Laird