Increased regional interleukin-4 during the acute stage of severe intracranial disorders
Increased regional interleukin-4 during the acute stage of severe intracranial disorders
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DOI：
10.2176/nmc.46.471
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发表时间：
2006-10-01
影响因子：
1.9
通讯作者：
Teramoto, Akira
中科院分区：
文献类型：
--
作者：
Katsuno, Makoto;Yokota, Hiroyuki;Teramoto, Akira
在急性期，在脑外伤，蛛网膜下腔出血，或脑出血患者颈内静脉白细胞介素（IL）-4水平进行了测量，以探讨预后价值。在入院时和发病后4小时测量颈内静脉中的IL-4、干扰素（IFN）-γ、葡萄糖和乳酸盐以及氧饱和度水平，以研究脑局部反应，并在桡动脉中作为对照。受试者被分为存活组和死亡组。在死亡组中，发病后4小时颈内静脉中的IL-4水平较高，动脉-颈静脉氧含量差（AjDO（2））较低。死亡组在发病后4小时发现葡萄糖和乳酸水平升高。IFN-γ无显著差异。使用AjDO（2）评估的脑疾病的严重程度与脑内IL-4水平呈负相关。这一发现表明，分泌的IL-4，具有神经保护作用，可能会增加与神经病变的严重程度，并可能是有用的预后指标。
Interleukin (IL)-4 levels in the internal jugular vein were measured during the acute stage in patients with head injuries, subarachnoid hemorrhage, or intracerebral hemorrhage to investigate the prognostic value. Levels of IL-4, interferon (IFN)-gamma, glucose, and lactate, and oxygen saturation were measured in the internal jugular vein to investigate cerebral local reactions and in the radial artery as a control at admission and 4 hours after onset. The subjects were divided into a survival group and a deceased group. IL-4 levels were high in the internal jugular veins and arterio-jugular venous differences in oxygen content (AjDO(2)) were low at 4 hours after onset in the deceased group. Increased glucose and lactate levels were found at 4 hours after onset in the deceased group. No significant difference was found for IFN-gamma. The severity of cerebral disorders evaluated using AjDO(2) showed a negative correlation with intracerebral IL-4 level. This finding suggests that secretion of IL-4, which has a neuroprotective effect, may increase with the severity of neuropathy and may be useful as a prognostic index.