Design and development of practical asymmetric syntheses of drug candidates
Design and development of practical asymmetric syntheses of drug candidates
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DOI：
10.1351/pac199769030453
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发表时间：
1997-03-01
影响因子：
1.8
通讯作者：
Shinkai, I
中科院分区：
文献类型：
--
作者：
Shinkai, I
不对称合成的最新进展对制药业的药物开发战略产生了重大影响。根据美国食品和药物管理局(FDA)最近的指导方针，许多制药公司不再考虑开发外消旋形式的手性药物。这个讲座提供了几个高度实用的候选药物的立体选择性合成的例子，如下所示，由默克研究实验室发现和开发。
Recent progress in asymmetric syntheses has made a significant impact on strategies for drug development in the pharmaceutical industry. Under the recent guidelines by the Food and Drug Administration (FDA), many drug firms are no longer considering the development of racemic forms of chiral drugs. This lecture presents a few examples of highly practical stereoselective syntheses of drug candidates, shown below, discovered and developed at Merck Research Laboratories.