The Effect of Phenobarbitone Anaesthesia on Blood Flow and Oxygen Consumption in the Rat Brain
The Effect of Phenobarbitone Anaesthesia on Blood Flow and Oxygen Consumption in the Rat Brain
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苯巴比妥麻醉对大鼠脑血流和耗氧量的影响
DOI：
10.1111/j.1399-6576.1975.tb05408.x
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发表时间：
1975
影响因子：
2.1
通讯作者：
B. K. Siesjô
中科院分区：
文献类型：
--
作者：
L. Nilsson;B. K. Siesjô
采用定量测量大脑皮质血流量的方法，观察苯巴比妥钠麻醉对大鼠脑血流量(CBF)和氧耗(CMRo2)的影响。这些数据与在芬太尼镇痛组动物身上获得的数据进行了比较。所有组的体温和动脉二氧化碳分压均维持在接近正常值的水平。加入50 mg/kg苯巴比妥钠后，CBF和CMRO2降低约20%。剂量为150或250 mg/kg时，CBF和CMRO2进一步降低。250 mg/kg时，CBF降至正常的1/3，CMRO2降至正常的50%左右。结果表明，如果苯巴比妥的剂量增加到250 mg/kg以上，预计CBF或CMRO2几乎不会进一步降低。
The influence of phenobarbitone anaesthesia on blood flow (CBF) and oxygen consumption (CMRo2) was evaluated in the rat brain, using a method that quantitatively measures CBF in mainly cortical areas. The data were compared to those obtained in animals under fentanyl citrate analgesia. Body temperature and arterial CO2 tension were maintained close to normal values in all groups. With 50 mg/kg of phenobarbitone, CBF and CMRO2 were reduced by about 20 %. With 150 or 250 mg/kg, further reductions in CBF and CMRO2 were observed. At 250 mg/kg, CBF was reduced to one third, and CMRO2 to about 50 % of normal. The results suggest that little further reduction in CBF or CMRO2 can be expected if the dose of phenobarbitone is increased above 250 mg/kg.