Effect of vitamin C and zinc on osmotic fragility and lipid peroxidation in zinc-deficient haemodialysis patients
Effect of vitamin C and zinc on osmotic fragility and lipid peroxidation in zinc-deficient haemodialysis patients
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DOI：
10.1002/cbf.947
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发表时间：
2002-06-01
影响因子：
3.6
通讯作者：
Candan, F
中科院分区：
文献类型：
--
作者：
Candan, F;Gültekin, F;Candan, F
红细胞膜脂结构过氧化导致血液透析患者溶血和贫血。膳食成分中的抗氧化维生素和微量元素可能在抗氧化损伤中起重要作用。本研究研究了补充维生素C和锌对34例缺锌血液透析患者红细胞渗透脆性和脂质过氧化的影响。16名性别和年龄相匹配的正常志愿者作为对照。患者随机接受维生素C（每天250毫克（-1））、锌（每天20毫克（-1））或安慰剂治疗3个月。在最初和补充后3个月测量维生素C、锌、丙二醛（MDA）和渗透脆弱性的水平。在各自的研究期结束时，各组血清维生素C和锌的平均浓度显著增加。补充维生素C和锌改善了各组的渗透脆弱性，降低了MDA水平，但在锌治疗期间观察到一些副作用（即恶心、呕吐、发烧、肌肉疼痛、无力）。结果表明，两种治疗方法的补充均可降低缺锌血液透析患者的渗透脆性和MDA。然而，维生素C治疗被发现比补充锌更安全。版权所有John Wiley Sons， Ltd。
Peroxidation of the membrane lipid structure of red blood cell leads to haemolysis and anaemia in haemodialysis patients. Dietary constituents of antioxidant vitamins and trace elements may play an important role in protecting against oxidant damage. In this study, the effects of supplementation of vitamin C and zinc on osmotic fragility and lipid peroxidation of erythrocytes were investigated in 34 zinc-deficient haemodialysis patients. Sixteen sex- and age-matched normal volunteers acted as controls. Patients were randomized to receive vitamin C (250 mg day(-1)), zinc (20 mg day(-1)) or a placebo treatment for 3 months. The levels of vitamin C, zinc, malondialdehyde (MDA) and osmotic fragility were measured initially and 3 months after supplementation. Mean serum concentration of vitamin C and zinc increased significantly in the groups at the end of the respective study periods. Supplementation with vitamin C and zinc improved osmotic fragility, and decreased the level of MDA in the groups, but some side-effects (i.e. nausea, vomiting, fever, muscle pain, weakness) were observed during the zinc treatment. The results showed that the supplementation of both treatments decreased osmotic fragilty and MDA in zinc-deficient haemodialysis patients. However, vitamin C treatment was found to be safer than zinc supplementation. Copyright (C) 2001 John Wiley Sons, Ltd.