LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice
LOX-1 abrogation reduces myocardial ischemia-reperfusion injury in mice
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DOI：
10.1016/j.yjmcc.2007.10.009
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发表时间：
2008-01-01
影响因子：
5
通讯作者：
Mehta, Jawahar L.
中科院分区：
文献类型：
--
作者：
Hu, Changping;Chen, Jiawei;Mehta, Jawahar L.
LOX-1是新近发现的氧化低密度脂蛋白凝集素样受体(OX-LDL)，在缺血心肌中高表达。为了探讨LOX-1在检测心脏缺血再灌注损伤中的致病作用，我们建立了LOX-1基因敲除(KO)小鼠，并对这些小鼠进行了60min的左冠状动脉阻断和60min的再灌流。LOX-1KO小鼠I-R损伤明显减轻，I-R心肌炎性细胞积聚和脂质过氧化作用明显减轻(P
LOX-1 is a newly described lectin-like receptor for oxidized-LDL (ox-LDL), which is over-expressed in the ischemic myocardium. To examine the pathogenic role of LOX-1 in the determination of ischemia-reperfusion (I-R) injury to the heart, we developed LOX-1 knockout(KO) mice, and subjected these mice to 60 min of left coronary artery occlusion followed by 60 min of reperfusion. I-R in the LOX-1 KO mice resulted in a significant reduction in myocardial injury as well as in accumulation of inflammatory cells in the I-R myocardium and lipid peroxidation (P