INFLAMMATORY MEDIATORS IN LATE ANTIGEN-INDUCED RHINITIS
INFLAMMATORY MEDIATORS IN LATE ANTIGEN-INDUCED RHINITIS
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DOI：
10.1056/nejm198507113130201
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发表时间：
1985-01-01
影响因子：
158.5
通讯作者：
LICHTENSTEIN, LM
中科院分区：
文献类型：
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作者：
NACLERIO, RM;PROUD, D;LICHTENSTEIN, LM
为探讨变态反应后期反应的机制，对12例变态反应患者用花粉抗原鼻腔激发后鼻分泌物中组胺、对甲苯磺酰-L-精氨酸甲酯酯酶（驯服）、激肽和前列腺素D_2（PG_D_2）进行了测定。9例患者在激发后3-11小时立即出现反应和症状复发。复发期间的临床症状伴随着组胺，TAME-酯酶和激肽水平超过基线值的第二次增加，虽然激肽水平低于即时响应期间。虽然PG D2的水平显着增加，在即时反应，他们没有增加到基线以上的晚期反应。在初始激发后11小时用变应原再激发与所有4种生化介质（包括PG D2）的重现相关。显然，对过敏原鼻腔激发的迟发反应伴随着组胺和TAME-酯酶浓度的第二次增加，但与立即反应不同的是缺乏PG D2的产生和产生的激肽的量。由于组胺仅由肥大细胞释放，而嗜碱性粒细胞不产生PG D2，因此这些细胞显然对晚期反应负有部分责任。
To investigate the mechanisms responsible for the late-phase response in patients with allergies, 4 biochemical mediators (histamine, tosyl-L-arginine methyl ester [TAME]-esterase, kinin and prostaglandin D2 [PG D2] were measured in nasal secretions after nasal challenge with pollen antigen in 12 patients with allergy. Nine patients had an immediate response and a recurrence of symptoms 3-11 h after challenge. The clinical symptoms during recurrence were accompanied by a second increase in levels of histamine, TAME-esterase and kinin over base-line values, although kinin levels were lower than during the immediate response. Although the levels of PG D2 were significantly increased during the immediate response, they did not increase above base line during the late response. Rechallenge with allergen 11 h after the initial provocation was associated with reappearance of all 4 biochemical mediators, including PG D2. Evidently, the late response to nasal challenge with allergen is accompanied by a second increase in the concentrations of histamine and TAME-esterase but differs from the immediate response in the lack of PG D2 production and in the amount of kinin generated. Since histamine is released only by mast cells and basophils PG D2 is not produced by basophils, these cells are apparently partly responsible for the late-phase response.