Clinical Implications of IL-32, IL-34 and IL-37 in Atherosclerosis: Speculative Role in Cardiovascular Manifestations of COVID-19.
Clinical Implications of IL-32, IL-34 and IL-37 in Atherosclerosis: Speculative Role in Cardiovascular Manifestations of COVID-19.
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DOI：
10.3389/fcvm.2021.630767
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发表时间：
2021
影响因子：
3.6
通讯作者：
Bao S
中科院分区：
文献类型：
--
作者：
Law CC;Puranik R;Fan J;Fei J;Hambly BD;Bao S
动脉粥样硬化是全世界心血管疾病 (CVD) 死亡的主要原因，是一种慢性炎症性疾病，其特征是动脉壁中脂质斑块的积累，引发由介导先天免疫和适应性免疫的细胞因子/趋化因子调节的炎症。本综述重点关注动脉粥样硬化患者稳定斑块与不稳定斑块中的 IL-32、-34 和 -37。在动脉粥样硬化斑块中发现了新型细胞因子 IL-32、-34 和 -37 的失调。 IL-32 和-34 具有促动脉粥样硬化作用，并与不稳定的斑块表型相关；而 IL-37 具有抗动脉粥样硬化作用并维持斑块稳定性。据推测，这些细胞因子可能有助于解释 COVID-19 感染患者中动脉粥样硬化斑块破裂发生率增加的原因。了解这些细胞因子在动脉粥样硬化形成中的作用可能会为不稳定斑块和急性冠状动脉综合征的治疗提供未来的治疗前景，并可能有助于我们对 COVID-19 细胞因子风暴的理解。
Atherosclerosis, which is a primary cause of cardiovascular disease (CVD) deaths around the world, is a chronic inflammatory disease that is characterised by the accumulation of lipid plaques in the arterial wall, triggering inflammation that is regulated by cytokines/chemokines that mediate innate and adaptive immunity. This review focuses on IL-32, -34 and -37 in the stable vs. unstable plaques from atherosclerotic patients. Dysregulation of the novel cytokines IL-32, -34 and -37 has been discovered in atherosclerotic plaques. IL-32 and -34 are pro-atherogenic and associated with an unstable plaque phenotype; whereas IL-37 is anti-atherogenic and maintains plaque stability. It is speculated that these cytokines may contribute to the explanation for the increased occurrence of atherosclerotic plaque rupture seen in patients with COVID-19 infection. Understanding the roles of these cytokines in atherogenesis may provide future therapeutic perspectives, both in the management of unstable plaque and acute coronary syndrome, and may contribute to our understanding of the COVID-19 cytokine storm.
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作者：
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DOI：
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发表时间：
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期刊：
Journal of geriatric cardiology : JGC
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