Nicotine absorption from e-cigarettes over 12 months
Nicotine absorption from e-cigarettes over 12 months
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DOI：
10.1016/j.addbeh.2018.07.019
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发表时间：
2019-04-01
影响因子：
4.4
通讯作者：
Dawkins, L. E.
中科院分区：
文献类型：
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作者：
Soar, K.;Kimber, C.;Dawkins, L. E.
背景：研究表明，随着时间的推移，电子烟的独家使用者（电子烟使用者）逐渐降低电子烟液中的尼古丁浓度，并转向更先进的设备。除此之外，电子烟油的消耗量增加并保持恒定的可替宁水平。 目的：我们旨在通过测量尼古丁吸收（通过尼古丁代谢物可替宁的唾液水平；ng/mL）、电子烟油中的尼古丁浓度（毫克/毫升）、消耗的电子烟油量（每天毫升）、使用的设备类型和口味，在基线和 12 个月后测试的 27 名经验丰富的电子烟使用者中确认这些观察结果。基线和 12 个月。结果：电子烟使用者在 12 个月内降低了电子烟液中的尼古丁浓度（从基线的 13.83 毫克/毫升到随访时的 9.91），但显着增加了电子烟液的消耗量（从 4.44 到 6.84 毫升）。未观察到唾液可替宁浓度发生显着变化（基线时为 370.88 ng/mL，随访时为 415.78 ng/mL）。 12 个月时，以及使用水果味电子烟油时，亚欧姆值（使用电阻 < 1 欧米茄的雾化器线圈，功率增加）有所增加。 结论：我们经验丰富的电子烟使用者样本随着时间的推移降低了电子烟油中的尼古丁浓度，但可能通过更强烈的抽吸进行自我滴定来维持尼古丁摄入量。研究结果表明，降低电子烟液中的尼古丁浓度可能没有什么好处，因为这似乎会导致电子烟液消耗量增加，从而可能产生财务和健康成本。了解降低电子烟液浓度的根本原因将是一个有用的实证研究途径。
Background: Research indicates that, over time, exclusive e-cigarette users (vapers) gradually reduce the nicotine concentration in their e-liquid and transition to more sophisticated devices. Alongside this, consumption of e-liquid increases and constant cotinine levels are maintained.Aims: We aimed to confirm these observations in 27 experienced vapers tested at baseline and 12 months later, by measuring nicotine absorption (via salivary levels of the nicotine metabolite cotinine; ng/mL), nicotine concentrations in e-liquid (mg/mL), volume of e-liquid consumed (mL per day), device types and flavours used, both at baseline and 12 months.Results: Vapers reduced both their nicotine concentrations in e-liquid over 12 months (from 13.83 mg/mL at baseline to 9.91 at follow up) but significantly increased their e-liquid consumption (from 4.44 to 6.84 mL). No significant changes in salivary cotinine concentrations (370.88 ng/mL at baseline and 415.78 ng/mL at follow up) were observed. There was an increase in sub-ohming (using an atomiser coil with resistance of < 1 Omega with increased power) at 12 months, and in the use of fruit flavoured e-liquids.Conclusions: Our sample of experienced vapers reduced the concentration of nicotine in their e-liquid over time, but maintained their nicotine intake possibly through self-titration via more intensive puffing. Findings suggest there may be little benefit in reducing nicotine e-liquid concentration since this appears to result in higher e-liquid consumption which may incur both a financial and health cost. Gaining an understanding of underlying reasons for lowering e-liquid concentration would be a useful line of empirical enquiry.