Identification and characterization of Th cell epitopes in MrkD adhesin of Klebsiella pneumoniae
Identification and characterization of Th cell epitopes in MrkD adhesin of Klebsiella pneumoniae
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DOI：
10.1016/j.micpath.2010.03.009
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发表时间：
2010-07-01
影响因子：
3.8
通讯作者：
Cu, Jing-min
中科院分区：
文献类型：
--
作者：
Li, Yang;Li, Zhi-jie;Cu, Jing-min
在本研究中，我们鉴定了肺炎克雷伯菌MrkD中的Th表位，这是一种优秀的疫苗候选抗原。通过使用RANKPEP预测算法，我们鉴定并表征了MrkD抗原中的三个Th表位，它们是M221-235，M175-189，这些表位对研究肺炎克雷伯菌感染后的免疫应答和设计有效的肺炎克雷伯菌疫苗具有重要价值。pneumoniae（C）2010 Elsevier Ltd版权所有
In this study, we identified the Th epitopes in MrkD of Klebsiella pneumoniae, an excellent vaccine candidate antigen By using the RANKPEP prediction algorithm, we have identified and characterized three Th epitopes within the MrkD antigen, which can be recognized by CD4+ T cells from BALB/c (H-2(d)) mice They were M221-235, M175-189, and M264-278 These epitopes have important value for studying the immune response of K pneumoniae infection and for designing effective vaccine against K. pneumoniae (C) 2010 Elsevier Ltd All rights reserved