Methods for Monitoring Risk of Hypoxic Damage in Fetal and Neonatal Brains: A Review.
Methods for Monitoring Risk of Hypoxic Damage in Fetal and Neonatal Brains: A Review.
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DOI：
10.1159/000520987
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发表时间：
2022
影响因子：
2.2
通讯作者：
Mehrmohammadi M
中科院分区：
文献类型：
--
作者：
Uzianbaeva L;Yan Y;Joshi T;Yin N;Hsu CD;Hernandez-Andrade E;Mehrmohammadi M
胎儿、围产期和新生儿窒息是人类最弱势群体（包括胎儿、新生儿和婴儿）的重要健康问题。胎儿大脑供氧和供血严重减少可引起缺氧缺血性脑病，导致长期神经系统疾病，包括精神障碍和脑瘫。这种神经系统疾病是主要的医疗保健问题。因此，人们一直在努力开发临床上有用的诊断工具，用于准确和定量地测量和监测胎儿和新生儿大脑的血液和氧气供应，以避免窒息缺氧缺血性脑病（HIE）和新生儿脑病（NE）的严重后果。用于此目的的主要诊断技术包括胎儿心率监测（FHRM）、胎儿头皮血液采样（FBS）、超声（US）成像、磁共振成像（MRI）、X射线计算机断层扫描（CT）和核医学。此外，鉴于传统诊断方法的局限性和缺点，近红外光谱（NIRS）和光声（PA）成像等新兴技术也被引入作为独立或补充解决方案，以解决胎儿和新生儿护理中的这一关键差距。本文综述了用于监测胎儿和新生儿脑氧合状态的传统和新兴技术的全面概述，并描述了其临床实用性，性能，优点和缺点。
Fetal, perinatal, and neonatal asphyxia are vital health issues for the most vulnerable groups in human beings, including fetuses, newborns, and infants. Severe reduction in oxygen and blood supply to the fetal brain can cause hypoxic-ischemic encephalopathy, leading to long-term neurological disorders, including mental impairment and cerebral palsy. Such neurological disorders are major healthcare concerns. Therefore, there has been a continuous effort to develop clinically useful diagnostic tools for accurately and quantitatively measuring and monitoring blood and oxygen supply to the fetal and neonatal brain to avoid severe consequences of asphyxia Hypoxic-Ischemic Encephalopathy (HIE) and Neonatal Encephalopathy (NE). Major diagnostic technologies used for this purpose include fetal heart rate monitoring (FHRM), fetus scalp blood sampling (FBS), ultrasound (US) imaging, magnetic resonance imaging (MRI), x-ray computed tomography (CT), and nuclear medicine. In addition, given the limitations and shortcomings of traditional diagnostic methods, emerging technologies such as near-infrared spectroscopy (NIRS) and photoacoustic (PA) imaging have also been introduced as stand-alone or complementary solutions to address this critical gap in fetal and neonatal care. This review provides a thorough overview of the traditional and emerging technologies for monitoring fetal and neonatal brain oxygenation status and describes their clinical utility, performance, advantages, and disadvantages.
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影响因子：
5.5
作者：
ANDERSON, PAW;GLICK, KL;MAINWARING, RD
通讯作者：
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DOI：
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