A gene mapping between the S and D regions of the H-2 complex influences resistance to Trichinella spiralis infections of mice.
A gene mapping between the S and D regions of the H-2 complex influences resistance to Trichinella spiralis infections of mice.
复制标题
H-2 复合物 S 区和 D 区之间的基因图谱影响小鼠对旋毛虫感染的抵抗力。
DOI：
10.1111/j.1744-313x.1983.tb00349.x
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
David,CS
中科院分区：
文献类型：
--
作者：
Wassom,DL;Brooks,BO;Babish,JG;David,CS
菌株b10。S(7r) b （10）S（23 R）和B（10）。S（24R）被认为基因相同，但对旋毛虫感染的易感性水平不同。在一系列的9个独立实验中，b10。S（7R）比其他两株更易感染。在另外一系列的七个实验中，菌株b10。A（18R）被证明更容易感染t。比菌株b10更螺旋。S（21R）或b10。BAR‐5，所有这些都被认为具有共同的h‐2等位基因。这些结果表明，沙地基因定位影响螺旋体感染的易感性。对这些菌株进行qandtlloci分型排除了双交叉的可能性，因为观察到的差异。新基因被命名为ts‐2。先前发表的数据也被重新解释，另一个基因被证明与a - β位点相关。当该等位基因在ts‐2位点表达时，表达ts‐1等位基因q的小鼠品系更易感染。
The strains B 10.S(7R), B 10.S(23 R) and B 10.S(24R), all thought to be genetically identical, differ in levels of susceptibility to infection withTrichinella spiralis. In a series of nine independent experiments, B 10.S(7R) was shown to be more susceptible than the other two strains. In another series of seven experiments, the strain B 10.A(18R) was shown to be more susceptible to infection withT.spiralisthan the strains B 10.S(21R) or B 10.BAR‐5, all of which were thought to share commonH‐2alleles. These results indicate that a gene mapping between theSandDloci influences susceptibility to infection withT.spiralis. Typing of these strains forQaandTlloci rule out the possibility of a double crossover accounting for the differences observed. The new gene is designatedTs‐2. Previously published data have also been reinterpreted and another geneTs‐1is shown to be associated with theAβlocus. When thedallele is expressed at theTs‐2locus, strains of mice expressings, q, forballeles atTs‐1are rendered more susceptible to infection.