KIRs and their HLA ligands in Remitting-Relapsing Multiple Sclerosis
KIRs and their HLA ligands in Remitting-Relapsing Multiple Sclerosis
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DOI：
10.1016/j.jneuroim.2010.08.004
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发表时间：
2010-12-15
影响因子：
3.3
通讯作者：
Lombardi, Maria Luisa
中科院分区：
文献类型：
--
作者：
Fusco, Caterina;Guerini, Franca Rosa;Lombardi, Maria Luisa
Killer Immunoglobulin-like Receptor (KIR) genes may affect both resistance and susceptibility to autoimmune disorders, but their role in the pathogenesis of Multiple Sclerosis (MS) is still unclear. To evaluate the involvement of KIRs and their HLA ligands in the development of MS we performed genotyping of HLA -A, -B, -Cw, -DRB1 and KIRs loci in 121 RRMS patients and 103 healthy controls (HC). Results evidenced a possible protective role of the activating KIR2DS1 gene (p(y) = 0.001; OR:0.38), enhanced in the presence of its ligand group HLA-C2 (p(y) = 0.0001; OR:0.23). Our data suggest that the presence of functional compounds of activating KIR receptors together with their HLA ligands, allowing the immunomodulatory function of NK cells, may have a protective role against the disease. (C) 2010 Elsevier B.V. All rights reserved.
