Leptin and energy restriction induced adaptation in energy expenditure
Leptin and energy restriction induced adaptation in energy expenditure
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DOI：
10.1016/j.metabol.2015.06.016
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发表时间：
2015-10-01
影响因子：
9.8
通讯作者：
Westerterp, Klaas R.
中科院分区：
文献类型：
--
作者：
Camps, Stefan G. J. A.;Verhoef, Sanne P. M.;Westerterp, Klaas R.
背景饮食诱导的体重减轻伴随着适应性产热，即静息能量消耗（REE）的不成比例减少，体力活动减少和运动经济性增加。确定能量限制诱导的适应性产热和体力活动的适应是否与瘦素浓度的变化有关。82名健康受试者（23名男性，59名女性），平均± SD年龄41 ± 8岁，BMI 31.9 ± 3.0 kg/m2，遵循极低能量饮食8周，在饮食前后进行测量。从空腹血浆测定瘦素浓度。采用基于体重、总身体水分（氘稀释）和身体体积（BodPod）的三室模型评估身体组成。PEE测量（REEm）与通风罩和预测（REEp）从measuredbody组成。适应性产热计算为REEm/REEp。身体活动量的参数是总能量消耗，表示为REEm（PAL）的倍数，活动引起的能量消耗除以体重（AEE/kg）和活动计数测量的三轴加速计。运动经济性计算为AEE/kg（MJ/kg/d）除以活动计数（Mcounts/d）。受试者平均体重减轻10.7 ± 4.1%（P < 0.001）。瘦素从饮食前的26.9 +/- 14.3 μ g/l降至饮食后的13.9 +/- 11.3 μ g/l（P < 0.001）。饮食后REEm/REEp（0.963 ± 0.08）与瘦素水平的变化相关（R-2 = 0.06; P < 0.05）。瘦素浓度的变化与体力活动量的变化之间没有显著相关性。运动经济性从0.036 ± 0.011 J/kg/计数变化到0.028 ± 0.010 J/kg/计数，与瘦素浓度的变化相关（R-2 = 0.07; P < 0.05）。在能量限制期间，瘦素的减少解释了适应性产热的部分变化。瘦素的变化与体力活动量无关，但可以部分解释运动经济的增加。(C)2015 Elsevier Inc. All rights reserved.
Background. Diet-induced weight loss is accompanied by adaptive thermogenesis, i.e. a disproportional reduction of resting energy expenditure (REE) a decrease in physical activity and increased movement economy.Objective. To determine if energy restriction induced adaptive thermogenesis and adaptations in physical activity are related to changes in leptin concentrations.Methods. Eighty-two healthy subjects (23 men, 59 women), mean +/- SD age 41 +/- 8 years and BMI 31.9 +/- 3.0 kg/m(2), followed a very low energy diet for 8 weeks with measurements before and after the diet. Leptin concentrations were determined from fasting blood plasma. Body composition was assessed with a three-compartment model based on body weight, total body water (deuterium dilution) and body volume (BodPod). PEE was measured (REEm) with a ventilated hood and predicted (REEp) from measuredbody composition. Adaptive thermogenesis was calculated as REEm/REEp. Parameters for the amount of physical activity were total energy expenditure expressed as a multiple of REEm (PAL), activity-induced energy expenditure divided by body weight (AEE/kg) and activity counts measured by a tri-axial accelerometer. Movement economy was calculated as AEE/kg (MJ/kg/d) divided by activity counts (Mcounts/d).Results. Subjects lost on average 10.7 +/- 4.1% body weight (P < 0.001). Leptin decreased from 26.9 +/- 14.3 before to 13.9 +/- 11.3 mu g/l after the diet (P < 0.001). REEm/REEp after the diet (0.963 +/- 0.08) was related to changes in leptin levels (R-2 = 0.06; P < 0.05). There was no significant correlation between changes in leptin concentrations and changes in amount of physical activity. Movement economy changed from 0.036 +/- 0.011 J/kg/count to 0.028 +/- 0.010 J/kg/count and was correlated to the changes in leptin concentrations (R-2 = 0.07; P < 0.05).Conclusion. During energy restriction, the decrease in leptin explains part of the variation in adaptive thermogenesis. Changes in leptin are not related to the amount of physical activity but could partly explain the increased movement economy. (C) 2015 Elsevier Inc. All rights reserved.