Alcohol consumption is associated with an increased risk of distal colon and rectal cancer in Japanese men: The Miyagi Cohort Study
Alcohol consumption is associated with an increased risk of distal colon and rectal cancer in Japanese men: The Miyagi Cohort Study
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DOI：
10.1016/j.ejca.2006.09.020
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发表时间：
2007-01-01
影响因子：
8.4
通讯作者：
Tsuji, Ichiro
中科院分区：
文献类型：
--
作者：
Akhter, Munira;Kuriyama, Shinichi;Tsuji, Ichiro
饮酒与近端或远端结肠或直肠癌风险之间的关系仍然存在争议。我们在一个大的基于人群的日本男性队列中研究了这种关联。1990年，向25，279名年龄在40至64岁之间的日本男性提供了一份关于饮酒和其他健康习惯的自填问卷。在排除基线时对饮酒或流行癌症病例做出不完整回答的受试者后，共有21，199名男性留下。其中，307名男性在随访11年后被诊断为结直肠癌。使用考克斯比例风险回归模型估计风险比（HR）和95%置信区间（CI），并对潜在混杂因素进行调整。与从不饮酒者相比，过去和现在饮酒者患结直肠癌的多变量风险比分别为1.1（95%CI，0.6-1.9）和1.6（95%CI，1.1-2.2）。在远端结肠和直肠癌中观察到当前饮酒量与剂量反应关系，但在近端结肠癌中未观察到。与从不饮酒者相比，目前大量饮酒者（每天45.6 g或更多乙醇）中远端结肠癌和直肠癌的多变量HR分别为4.2（1.6-10.7;趋势p = 0.0002）和1.8（1.1-3.2;趋势p = 0.04）。相比之下，未发现近端结肠癌的显著线性相关性（趋势p = 0.2）。这些数据表明，日本男性饮酒与远端结肠癌和直肠癌的统计学显著增加相关，但与近端结肠癌无关。(c)2006爱思唯尔有限公司保留所有权利。
The association between alcohol consumption and the risk of cancer of the proximal or-distal colon or rectum remains controversial. We examined this association in a large population-based cohort of Japanese men. In 1990, a self-administered questionnaire on alcohol drinking and other health habits was delivered to 25,279 Japanese men aged 40 to 64 years of age. After exclusion of subjects who gave incomplete responses on alcohol drinking or prevalent cancer cases at the baseline, a total of 21,199 men remained. Of these, 307 men were diagnosed as having colorectal cancer after 11 years of follow-up. Cox proportional hazards regression models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs), with adjustments made for potential confounders. Compared with never drinkers, past and current drinkers had multivariate HRs of 1.1 (95% CI, 0.6-1.9) and 1.6 (95% CI, 1.1-2.2) for colorectal cancer, respectively A dose-response relationship with current volume of alcohol drinkers was observed for cancer of the distal colon and rectum, but not for proximal colon. The multivariate HRs for distal colon and rectal cancer among current heavy drinkers (45.6 g or more ethanol per day) as compared with never drinkers were 4.2 (1.6-10.7; p for trend = 0.0002) and 1.8 (1.1-3.2; p for trend = 0.04), respectively. In contrast, no significant linear association was found for proximal colon cancer (p for trend = 0.2). These data indicate that alcohol consumption in Japanese men is associated with a statistically significant increased risk of cancer of the distal colon and rectum, but not cancer of the proximal colon. (c) 2006 Elsevier Ltd. All rights reserved.