Nuclear factor-kappaB to the rescue of cytokine-induced neuronal survival.
Nuclear factor-kappaB to the rescue of cytokine-induced neuronal survival.
复制标题
核因子 - 卡帕布（Kappab）营救细胞因子诱导的神经元存活。
DOI：
10.1083/jcb.148.2.223
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发表时间：
2000-01-24
影响因子：
7.8
通讯作者：
Ernfors, P
中科院分区：
文献类型：
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作者：
Ernfors, P
在脊椎动物神经系统的发育过程中，神经元及其突触的形成与神经元死亡和突触重塑之间保持平衡。已知神经营养细胞因子在发育期间促进某些类别的神经元的存活。然而，这些细胞因子激活的信号通路尚未确定。在这个问题上，Middleton et al.（2000）提供了神经营养细胞因子激活转录因子核因子κ B（NFκB B）的证据，其对于细胞因子依赖性神经元的存活至关重要。这被认为是为了确保正确数量和类型的神经元支配靶细胞。神经元的存活或死亡决定似乎不是预先确定的，而是由外部刺激激活的多个细胞内信号通路整合的结果。这种外部刺激包括神经营养因子，其以有限的量存在。获得所需神经营养因子的充足供应的神经元存活，而在竞争中失败的神经元死亡。
During the development of the vertebrate nervous system, a balance is maintained between the formation of neurons and their synapses and neuronal death and synaptic remodeling. Neurotrophic cytokines are known to promote the survival of certain classes of neurons during development. The signaling pathways activated by these cytokines, however, have not been defined. In this issue, Middleton et al.(2000) provides evidence that neurotrophic cytokines activate the transcription factor nuclear factor kappa B (NFκB), which is crucial for the survival of cytokine dependent neurons.In many populations of developing neurons, more than half of the neurons generated die by apoptosis. This is believed to ensure that the correct number and type of neurons innervate target cells. The survival or death decision of neurons appears not to be predetermined, but is instead the consequence of the integration of multiple intracellular signaling pathways activated by external stimuli. Such external stimuli include neurotrophic factors, which are present in limiting quantities. Neurons that obtain an adequate supply of the required neurotrophic factor survive, whereas neurons that are unsuccessful in the competition die.