The roles of individual polyoma virus early proteins in oncogenic transformation
The roles of individual polyoma virus early proteins in oncogenic transformation
复制标题
单个多瘤病毒早期蛋白在致癌转化中的作用
作者：
M. Rassoulzadegan;A. Cowie;A. Carr;N. Glaichenhaus;R. Kamen;F. Cuzin
在正常大鼠细胞中表达的修改多瘤病毒基因组，分别编码大T，中T或小T抗原，允许调查这些蛋白质的致癌转化的作用。中T足以转化已建立系的细胞，但转化体具有血清依赖性。大T缺乏内在的致癌潜力，但可以减轻正常和转化细胞的血清依赖性。单独的中T不能转化原代大鼠胚胎成纤维细胞。
The expression in normal rat cells of modified polyoma virus genomes, separately encoding large T, middle T or small T antigens, has allowed the investigation of the roles of these proteins in oncogenic transformation. Middle T is sufficient to transform cells of established lines but the transformants are serum dependent. Large T lacks intrinsic oncogenic potential but can relieve the serum dependence of normal and transformed cells. Middle T alone cannot transform primary rat embryo fibroblasts.
仅含有部分早期区域的克隆多瘤病毒 DNA 片段对大鼠胚胎成纤维细胞的转化。
DOI：
10.1073/pnas.77.7.3978
发表时间：
1980
影响因子：
11.1
作者：
Hassell,JA;Topp,WC;Rifkin,DB;Moreau,PE
通讯作者：
Moreau,PE