The vit gene maps to the mi (microphthalmia) locus of the laboratory mouse.
The vit gene maps to the mi (microphthalmia) locus of the laboratory mouse.
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vit 基因映射到实验室小鼠的 mi（小眼症）基因座。
DOI：
10.1093/oxfordjournals.jhered.a111247
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发表时间：
1992
期刊：
影响因子：
--
通讯作者：
James J. Nordlund
中科院分区：
文献类型：
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作者：
M. Lamoreux;Raymond E. Boissy;James E. Womack;James J. Nordlund
人类白癜风的小鼠模型（vit/vit小鼠）出现皮毛、皮肤和眼睛的进行性色素脱失。维生素基因是一种常染色体隐性遗传。我们已经使用了经典的育种和同工酶标记分析，以映射这种维生素基因，产生白癜风样的条件下，在小鼠。将C57 BL/6 J-vit/vit小鼠与在小眼症基因座处携带Miwh和/或miws等位基因的C57 BL/6 J小鼠杂交导致突变表型，证明不存在互补。当维生素与Miwh等位基因杂合时，产生“斑点”色素模式。当它与miws等位基因杂合时，产生白癜风表型的新表达。这些杂交种群的进一步交配分析表明，在小眼症基因座的等位基因之间的等位基因遗传的维生素。其他育种研究使用等位基因在agglomerate，带状，棕色，显性斑点，延伸，桃花心木，补丁，花斑位点没有表现出色素沉着的等位基因遗传与维生素基因的解释。此外，维生素与位于第1、4、5、7、9和11号染色体上的同工酶标记进行了连锁检测，结果均为阴性。因此，实验室小鼠的vit（白癜风）基因已被定位到6号染色体上的mi（小眼）位点。该基因应正确命名为mivit。
The murine model for human vitiligo (the vit/vit mouse) develops progressive depigmentation of the pelage, skin, and eyes. The vit gene is inherited as an autosomal recessive. We have used classical breeding and isozyme marker analysis to map this vit gene that produces a vitiligo-like condition in the mouse. Crossbreeding the C57BL/6J-vit/vit mice with C57BL/6J mice carrying the Miwh and/or miws alleles at the microphthalmia locus resulted in mutant phenotypes, demonstrating absence of complementation. When vit is heterozygous with the Miwh allele, a "blotched" pigment pattern results. When it is heterozygous with the miws allele, a novel expression of the vitiliginous phenotype results. Further mating analysis of these crossbred populations demonstrates allelic inheritance between vit and the alleles at the microphthalmia locus. Other breeding studies using alleles at the agouti, belted, brown, dominant spotting, extension, mahogany, patch, and piebald loci did not demonstrate pigmentation explainable by allelic inheritance with the vit gene. Also, vit was tested for linkage with isozyme markers located on chromosomes 1, 4, 5, 7, 9, and 11, and results were negative. Therefore, the vit (vitiligo) gene of the laboratory mouse has been mapped to the mi (microphthalmia) locus on chromosome 6. The gene properly should be designated as mivit.