Age and Gender Disparities in Adverse Events Following COVID-19 Vaccination: Real-World Evidence Based on Big Data for Risk Management.
Age and Gender Disparities in Adverse Events Following COVID-19 Vaccination: Real-World Evidence Based on Big Data for Risk Management.
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DOI：
10.3389/fmed.2021.700014
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发表时间：
2021
影响因子：
3.9
通讯作者：
Lu ZK
中科院分区：
文献类型：
--
作者：
Xiong X;Yuan J;Li M;Jiang B;Lu ZK
工作背景：两种2019冠状病毒病（COVID-19）疫苗已在美国获得紧急使用授权，然而，这些疫苗在现实世界中的安全性仍然未知。研究方法：我们审查了2020年12月14日至2021年1月22日期间疫苗不良事件报告系统（VAERS）中成人接种COVID-19疫苗后的不良事件（AE）。我们按年龄（18-64岁，≥65岁）和性别（女性，男性）比较了前10例AE（严重AE），沿着诊室和急诊室（ER）访视。结果：在COVID-19疫苗接种后发生AE的成年人中存在年龄和性别差异。与18 - 64岁的年轻人相比，老年人更有可能报告严重AE、死亡、永久性残疾和住院治疗。与女性相比，男性更有可能报告严重不良事件、死亡和住院。结论：COVID-19疫苗通常是安全的，但报告的AE可能存在年龄和性别差异。
Background: Two coronavirus disease 2019 (COVID-19) vaccines have received emergency use authorizations in the U.S. However, the safety of these vaccines in the real-world remains unknown. Methods: We reviewed adverse events (AEs) following COVID-19 vaccination among adults in the Vaccine Adverse Event Reporting System (VAERS) from December 14, 2020, through January 22, 2021. We compared the top 10 AEs, serious AEs, along with office and emergency room (ER) visits by age (18–64 years, ≥65 years) and gender (female, male). Results: There were age and gender disparities among adults with AEs following COVID-19 vaccination. Compared to younger adults aged between 18 and 64 years, older adults were more likely to report serious AEs, death, permanent disability, and hospitalization. Males were more likely to report serious AEs, death, and hospitalization compared to females. Conclusions: COVID-19 vaccines are generally safe but possible age and gender disparities in reported AEs may exist.