Presurgical cognitive deficits in patients receiving coronary artery bypass graft surgery.
Presurgical cognitive deficits in patients receiving coronary artery bypass graft surgery.
复制标题
接受冠状动脉搭桥手术的患者术前认知缺陷。
DOI：
10.1017/s1355617703960115
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发表时间：
2003
期刊：
影响因子：
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通讯作者：
Buckwalter,JGalen
中科院分区：
文献类型：
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作者：
Rankin,KatherineP;Kochamba,GaryS;Boone,KyleB;Petitti,DianaB;Buckwalter,JGalen
Coronary artery bypass graft (CABG) surgery with cardiopulmonary bypass (CPB) can produce a higher incidence of neuropsychological complications than other types of highly invasive noncardiac vascular surgery. Cognitive complications most likely arise from either embolization or hypoxia. An alternative surgical procedure has been developed that allows CABG to be performed without stopping the heart (“off-pump” CABG, or OPCABG). This study examined the neuropsychological performance of patients undergoing OPCABG, hypothesizing that patients undergoing OPCABG would show fewer cognitive deficits than patients whose hearts were stopped. A 1-hr neuropsychological battery was administered preoperatively to 43 patients before prospective randomization to either CPB CABG or OPCABG, and again to 34 of those patients 2 to 3 months postoperatively by an examiner blind to surgical condition. Neuropsychological status did not change 2.5 months postsurgically in either OPCABG or CABG groups. However, both groups showed dramatic presurgical cognitive deficits in multiple domains, particularly verbal memory and psychomotor speed. This corroborates previous research suggesting that patients requiring CABG surgery may evidence significant presurgical cognitive deficits as a result of existing vascular disease. (JINS, 2003, 9, 913–924.)
