Molecular actions of calcineurin inhibitors
Molecular actions of calcineurin inhibitors
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DOI：
10.1358/dnp.2003.16.5.829315
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发表时间：
2003-06-01
影响因子：
--
通讯作者：
Hamawy, MM
中科院分区：
文献类型：
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作者：
Hamawy, MM
免疫抑制药物环孢素A和FK-506，也称为钙调磷酸酶抑制剂，已用于治疗免疫系统介导的疾病，并真正彻底改变了同种异体移植。这两种药物通过抑制关键信号磷酸酶钙调磷酸酶的机制阻断T细胞增殖，因此称为钙调磷酸酶抑制剂。环孢菌素A和FK-506对钙调磷酸酶激活的抑制阻断了T细胞受体介导的白细胞介素-2（IL-2）的产生，白细胞介素-2是T细胞增殖的关键生长因子。然而，最近的研究表明，药物的作用不仅限于阻断钙调磷酸酶激活和IL-2的产生。本文综述了环孢素A和FK-506的分子作用。(C)2003年，《科学》杂志。All rights reserved.
The immunosuppressive drugs cyclosporin A and FK-506, also called calcineurin inhibitors, have been useful for treating immune system-mediated diseases and have truly revolutionized allograft transplantation. Both drugs block T-cell proliferation by mechanisms that involve the inhibition of the key signaling phosphatase calcineurin, hence, the name calcineurin inhibitors. The inhibition of calcineurin activation by cyclosporin A and FK-506 blocks T-cell receptor-mediated production of interleukin-2 (IL-2), a growth factor critical for T-cell proliferation. Recent studies, however, suggest that the effects of the drugs are not limited to blocking calcineurin activation and IL-2 production. This review discusses the molecular actions of cyclosporin A and FK-506. (C) 2003 Prous Science. All rights reserved.