Role of locus coeruleus in attention and behavioral flexibility
Role of locus coeruleus in attention and behavioral flexibility
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DOI：
10.1016/s0006-3223(99)00140-7
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发表时间：
1999-11-01
影响因子：
10.6
通讯作者：
Cohen, J
中科院分区：
文献类型：
--
作者：
Aston-Jones, G;Rajkowski, J;Cohen, J
先前的发现暗示了去甲肾上腺素基因座（LC）系统沿唤醒或注意力的维度。它仍然不确定该系统在注意力中的作用，或可能涉及哪些机制。我们回顾了我们最近检查猴子中LC神经元的活动的工作，执行了需要集中注意力的视觉歧视任务。结果表明，LC细胞表现出阶段性或滋补活性模式，分别与该任务上的良好或差的表现非常相对应。使用计算模型来模拟这些结果。该模型预测，LC细胞之间电子耦合的变化可能会产生不同的活性模式和相应的性能差异。该模型还表明，LC活性的阶段模式可能会促进聚焦或选择性的关注，而补品模式可能会产生高行为灵活性或扫描专注力的状态。讨论了这些结果对临床疾病的含义，例如注意力缺陷多动障碍障碍以及情绪和情感障碍。 （c）1999年生物精神病学会。
Previous findings have implicated the noradrenergic locus coeruleus (LC) system in functions along the dimension of arousal or attention. It has remained uncertain what role this system has in attention, or what mechanisms may be involved. We review our recent work examining activity of LC neurons in monkeys performing a visual discrimination task that requires focused attention. Results indicate that LC cells exhibit phasic or tonic modes of activity, that closely correspond to good or poor performance on this task, respectively. A computational model was used to simulate these results. This model predicts that alterations in electrotonic coupling among LC cells may produce the different modes of activity and corresponding differences in performance. This model also indicates that the phasic mode of LC activity may promote focused or selective attention, whereas the tonic mode may produce a state of high behavioral flexibility or scanning attentiveness. The implications of these results for clinical disorders such as attention-deficit hyperactivity disorder stress disorders, and emotional and affective disorders are discussed. (C) 1999 Society of Biological Psychiatry.