Comparison of clinicopathologic characteristics and genetic alterations between microsatellite instability-positive and microsatellite instability-negative sporadic colorectal carcinomas in patients younger than 40 years old
Comparison of clinicopathologic characteristics and genetic alterations between microsatellite instability-positive and microsatellite instability-negative sporadic colorectal carcinomas in patients younger than 40 years old
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DOI：
10.1007/s10350-004-6152-x
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发表时间：
2002-02-01
影响因子：
3.9
通讯作者：
Kang, GH
中科院分区：
文献类型：
--
作者：
Suh, JH;Lim, SD;Kang, GH
目得：许多研究表明，散发性微卫星不稳定性阳性结直肠癌与遗传性非息肉病性结直肠癌具有一些共同的临床病理特征，包括右侧位置，年轻的发病年龄，特征性组织形态学特征和良好的预后。本研究的目的是确定散发性微卫星不稳定性阳性结直肠癌的独特临床病理特征，并比较年轻组中微卫星不稳定性阳性和微卫星不稳定性阴性结直肠癌之间的基因型特征。方法：对61例青年患者的临床资料进行分析。
PURPOSE: Many studies have demonstrated that sporadic microsatellite instability-positive colorectal cancers share several clinicopathologic features with hereditary nonpolyposis colorectal cancers, including right-sided location, young age of onset, characteristic histomorphologic features, and a good prognosis. The aim of this study was to define distinct clinicopathologic features of sporadic microsatellite instability-positive colorectal cancers and to compare genotypic characteristics between microsatellite instability-positive and microsatellite instability-negative colorectal cancers in a young group. METHODS: We analyzed 61 cases of young patients (