Oscillapeptins A to F, serine protease inhibitors from the three strains of Oscillatoria agardhii
Oscillapeptins A to F, serine protease inhibitors from the three strains of Oscillatoria agardhii
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DOI：
10.1016/s0040-4020(99)00341-5
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发表时间：
1999-05-28
期刊：
影响因子：
2.1
通讯作者：
Murakami, M
中科院分区：
文献类型：
--
作者：
Itou, Y;Ishida, K;Murakami, M
从培养的三株agardhii振荡蓝藻中分离到振荡apeptin B (2) ~ F(6)，它们是振荡apeptin A(1)的同系物。这些结构是通过包括二维核磁共振技术在内的光谱分析确定的。用光谱法和化学法测定了振荡肽的绝对构型。振荡apeptin A(1)至E(5)抑制凝乳胰蛋白酶和/或弹性蛋白酶，振荡apeptin F(6)抑制胰蛋白酶和纤溶酶。1999爱思唯尔科学有限公司版权所有。
Oscillapeptins B (2) to F (6), which were congeners of oscillapeptin A (1), were isolated from the three strains of cultured cyanobacterium Oscillatoria agardhii. These structures were established by spectroscopic analysis including the 2D NMR techniques. The absolute configurations of oscillapeptins were determined by the spectral and chemical methods. Oscillapeptins A (1) to E (5) inhibited chymotrypsin and/or elastase, and oscillapeptin F (6) inhibited trypsin and plasmin. (C) 1999 Elsevier Science Ltd. All rights reserved.