Effects of diazepam or chronic alcohol treatment on spatial reversal learning in mice
Effects of diazepam or chronic alcohol treatment on spatial reversal learning in mice
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DOI：
10.1016/s0091-3057(98)00211-1
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发表时间：
1999-04-01
影响因子：
3.6
通讯作者：
Beracochea, DJ
中科院分区：
文献类型：
--
作者：
Borde, N;Beracochea, DJ
长期饮酒组（CAC； 11个月）和系统地西泮组小鼠接受空间逆转学习任务训练。尽管cac治疗的小鼠能够以正常的速度学习初始习得，但它们在第一次歧视逆转和随后的逆转过程中受到损害。相比之下，地西泮没有引起任何行为测量的缺陷。综上所述，CAC，而不是地西泮，诱导了对主动干扰的过度敏感性。然而，这两种治疗方法没有导致学习集曲线的发展。这些结果与临床数据一致，表明非陈述性或内隐形式的记忆过程在地西泮治疗的受试者或慢性酗酒者中得以保留。(C) 1999 Elsevier Science Inc.；
Mice submitted to chronic alcohol consumption (CAC; 11 months) or to systemic diazepam administration were trained in a spatial reversal learning task. Although CAC-treated mice were able to learn the initial acquisition at normal rates, they were impaired during the first reversal of the discrimination and subsequent reversal sessions. In contrast, diazepam administration induced no deficits for any behavioral measure. In conclusion, CAC, but not diazepam administration, induces an exaggerated sensitivity to proactive interference. The two treatments spared, however, the development of the learning set curve. These results are congruent with clinical data showing that nondeclarative or implicit forms of memory processes are spared in diazepam-treated subjects or in chronic alcoholics. (C) 1999 Elsevier Science Inc.