Transcranial Focused Ultrasound Neuromodulation of Voluntary Movement-Related Cortical Activity in Humans.
Transcranial Focused Ultrasound Neuromodulation of Voluntary Movement-Related Cortical Activity in Humans.
复制标题
经颅聚焦超声对人类自主运动相关皮质活动的神经调节。
DOI：
10.1109/tbme.2020.3030892
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发表时间：
2021-06
期刊：
影响因子：
--
通讯作者：
He B
中科院分区：
文献类型：
--
作者：
Yu K;Liu C;Niu X;He B
经颅聚焦超声（tFUS）是一种新兴的非侵入性脑刺激工具，用于安全和可逆地调节脑回路。tFUS对人脑的有效性已被证实，但tFUS如何影响人脑中的人类自主运动加工仍不清楚。我们应用低强度tFUS来调节源于人类受试者练习自愿足部敲击任务的运动相关皮层电位（MRCP）。64-通道脑电图（EEG）被同时记录，并进一步用于使用电生理源成像（ESI）来重建特定于初级腿部运动皮层区的脑源活动。ESI图示了具有高时空分辨率的超声调制MRCP源动力学。对MRCP源进行成像，并进一步评估其源轮廓，以评估tFUS对自愿MRCP的神经调节作用。此外，超声脉冲重复频率（UPRF）的影响，进一步评估调制MRCP。ESI结果表明，与假超声条件相比，tFUS显著增加了MRCP源轮廓幅度（MSPA），并且高UPRF比低UPRF更能增强MSPA。本研究结果表明，低强度tFUS对增强人类自主运动相关的皮层活动的神经调节作用，通过ESI成像证明。这项工作提供了第一个证据，tFUS通过兴奋性调制增强人类内源性运动皮层活动。
Transcranial focused ultrasound (tFUS) is an emerging non-invasive brain stimulation tool for safely and reversibly modulating brain circuits. The effectiveness of tFUS on human brain has been demonstrated, but how tFUS influences the human voluntary motor processing in the brain remains unclear. We apply low-intensity tFUS to modulate the movement-related cortical potential (MRCP) originating from human subjects practicing a voluntary foot tapping task. 64-channel electroencephalograph (EEG) is recorded concurrently and further used to reconstruct the brain source activity specifically at the primary leg motor cortical area using the electrophysiological source imaging (ESI). The ESI illustrates the ultrasound modulated MRCP source dynamics with high spatiotemporal resolutions. The MRCP source is imaged and its source profile is further evaluated for assessing the tFUS neuromodulatory effects on the voluntary MRCP. Moreover, the effect of ultrasound pulse repetition frequency (UPRF) is further assessed in modulating the MRCP. The ESI results show that tFUS significantly increases the MRCP source profile amplitude (MSPA) comparing to a sham ultrasound condition, and further, a high UPRF enhances the MSPA more than a low UPRF does. The present results demonstrate the neuromodulatory effects of the low-intensity tFUS on enhancing the human voluntary movement-related cortical activities evidenced through the ESI imaging. This work provides the first evidence of tFUS enhancing the human endogenous motor cortical activities through excitatory modulation.