Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro.
Cerebrospinal fluid inhibits Alzheimer beta-amyloid fibril formation in vitro.
复制标题
脑脊液在体外抑制阿尔茨海默β-淀粉样原纤维的形成。
DOI：
10.1002/ana.410340422
复制
发表时间：
1993
影响因子：
11.2
通讯作者：
Frangione,B
中科院分区：
文献类型：
--
作者：
Wisniewski,T;Castano,E;Ghiso,J;Frangione,B
阿尔茨海默病的特征在于β蛋白（Aβ）沉积为淀粉样蛋白。近年来发现Aβ是血清和脑脊液中的正常成分。与Aβ同源的合成肽在水或生理溶液中自发形成淀粉样纤维。使用与Aβ1-40同源的肽，我们发现脑脊液的存在抑制了原纤维的形成。
Alzheimer's disease is characterized by the deposition of β‐protein (Aβ) as amyloid. Recently, it was found that Aβ is a normal component of serum and cerebrospinal fluid. Synthetic peptides homologous to Aβ form amyloid‐like fibrils spontaneously in water or physiological solutions. Using a peptide homologous to Aβ1–40, we find that fibril formation is inhibited by the presence of cerebrospinal fluid.