Transcription of the terminal loop region of vaccinia virus DNA is initiated from the telomere sequences directing DNA resolution.
Transcription of the terminal loop region of vaccinia virus DNA is initiated from the telomere sequences directing DNA resolution.
复制标题
痘苗病毒 DNA 末端环区域的转录是从指导 DNA 解析的端粒序列开始的。
DOI：
10.1016/0042-6822(91)90905-q
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发表时间：
1991
期刊：
影响因子：
3.7
通讯作者：
Pickup,DJ
中科院分区：
文献类型：
--
作者：
Hu,FQ;Pickup,DJ
牛痘病毒DNA的端粒在感染后的晚期转录。病毒DNA末端环区RNA转录物的cDNA分析表明，末端环区的反向和互补形式都被转录。这些含有5' poly（A）序列的晚期RNA似乎不编码任何蛋白质。这些RNA中的大多数的转录起始位点在指导多联体DNA复制中间体的分解的序列内（M. Merchlinsky和B。Moss，1989，J. ViroL 63，4354-4361）。这表明DNA解析的过程可能涉及从解析所需的端粒序列开始的转录。
The telomeres of vaccinia virus DNA are transcribed at late times after infection. Analysis of cDNAs of RNA transcripts of the terminal loop region of the viral DNA shows that both inverted and complementary forms of the terminal loop region are transcribed. These late RNAs, which contain 5' poly(A) sequences, do not appear to encode any proteins. The transcriptional start sites for most of these RNAs are within the sequences that direct the resolution of concatemeric DNA replication intermediates (M. Merchlinsky and B. Moss, 1989, J. ViroL 63, 4354–4361). This suggests that the process of DNA resolution may involve transcription initiated from the telomere sequences required for resolution.