HB‐EGF decelerates cell proliferation synergistically with TGFα in perinatal distal lung development
HB‐EGF decelerates cell proliferation synergistically with TGFα in perinatal distal lung development
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DOI：
10.1002/dvdy.21398
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发表时间：
2008-01
影响因子：
2.5
通讯作者：
S. Minami;R. Iwamoto;E. Mekada
中科院分区：
文献类型：
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作者：
S. Minami;R. Iwamoto;E. Mekada
肝素结合表皮生长因子样生长因子（HB-EGF）是EGF生长因子家族的成员，被认为参与远端肺发育。在HB-EGF null（HBdel/del）新生儿中，组织病理学分析显示从胚胎第18.5天开始出现异常厚的囊壁，减少了终末囊腔面积。HB-EGF基因缺失导致细胞增殖显著增加，表明HB-EGF抑制远端肺细胞增殖。此外，对HB-EGF和转化生长因子-α（TGFα）双突变体新生儿的囊状形态和增殖的分析表明，HB-EGF和TGFα在这种抑制中协同作用。最后，HBdel/del小鼠和waved 2小鼠（一种亚型EGF受体（EGFR）突变株）之间的杂交表明，HB-EGF和EGFR在这一过程中协同作用。因此，HB-EGF具有一种新的抑制功能，有助于在围产期远端肺发育中通过EGFR与TGFα协同减缓远端肺细胞增殖。发展动力学237：247-258，2008年。© 2007 Wiley利斯公司
Heparin‐binding epidermal growth factor‐like growth factor (HB‐EGF) is a member of the EGF family of growth factors that is suggested to be involved in distal lung development. In HB‐EGF null (HBdel/del) newborns, a histopathologic analysis revealed abnormally thick saccular walls occurring from embryonic day 18.5 that reduced the terminal saccular space area. HB‐EGF gene deletion resulted in a significant increase in cell proliferation, indicating that HB‐EGF suppresses distal lung cell proliferation. Furthermore, an analysis of saccular morphology and proliferation in HB‐EGF and transforming growth factor‐α (TGFα) double‐mutant newborns revealed that HB‐EGF and TGFα function synergistically in this suppression. Finally, crosses between HBdel/del mice and waved 2 mice, a hypomorphic EGF receptor (EGFR) mutant strain, suggest that HB‐EGF and EGFR cooperate in this process. Thus, HB‐EGF has a novel suppressive function that contributes to decelerating distal lung cell proliferation synergistically with TGFα through EGFR in perinatal distal lung development. Developmental Dynamics 237:247–258, 2008. © 2007 Wiley‐Liss, Inc.