Interactions between sleep, circadian function, and glucose metabolism: implications for risk and severity of diabetes
Interactions between sleep, circadian function, and glucose metabolism: implications for risk and severity of diabetes
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DOI：
10.1111/nyas.12355
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发表时间：
2014-01-01
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影响因子：
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通讯作者：
Van Cauter, Eve
中科院分区：
文献类型：
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作者：
Reutrakul, Sirimon;Van Cauter, Eve
睡眠障碍，包括睡眠不足和睡眠碎片，与葡萄糖代谢异常和糖尿病风险增加有关。控制良好的实验室研究提供了关于潜在机制的见解。几项大型前瞻性研究表明，这些睡眠障碍与糖尿病发病风险增加有关。阻塞性睡眠呼吸暂停综合了睡眠片段和低氧血症，是胰岛素抵抗和可能的糖尿病的主要危险因素。2型糖尿病患者的血糖控制是否可以通过治疗睡眠呼吸暂停来改善仍然存在争议。最近，由于对母亲和胎儿健康的潜在不利影响，妊娠期睡眠障碍及其与妊娠期糖尿病和高血糖症的关系受到了相当大的关注。此外，来自动物模型的证据已经将昼夜节律系统的破坏确定为不良代谢结果的假定风险因素。这篇综述的目的是提供一个最新的知识状态连接睡眠障碍，昼夜节律功能障碍和葡萄糖代谢。实验，前瞻性和干预性研究进行了讨论。
Sleep disturbances, including sleep insufficiency and sleep fragmentation, have been linked to abnormal glucose metabolism and increased diabetes risk. Well-controlled laboratory studies have provided insights regarding the underlying mechanisms. Several large prospective studies suggest that these sleep disturbances are associated with an increased risk of incident diabetes. Obstructive sleep apnea, which combines sleep fragmentation and hypoxemia, is a major risk factor for insulin resistance and possibly diabetes. Whether glycemic control in type 2 diabetes patients can be improved by treating sleep apnea remains controversial. Recently, sleep disturbances during pregnancy and their relationship to gestational diabetes and hyperglycemia have received considerable attention owing to potential adverse effects on maternal and fetal health. Additionally, evidence from animal models has identified disruption of the circadian system as a putative risk factor for adverse metabolic outcomes. The purpose of this review is to provide an update on the current state of knowledge linking sleep disturbances, circadian dysfunction, and glucose metabolism. Experimental, prospective, and interventional studies are discussed.