Involvement of the plant nucleolus in virus and viroid infections: parallels with animal pathosystems.
Involvement of the plant nucleolus in virus and viroid infections: parallels with animal pathosystems.
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DOI：
10.1016/b978-0-12-385034-8.00005-3
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发表时间：
2010
影响因子：
--
通讯作者：
Kalinina NO
中科院分区：
文献类型：
--
作者：
Taliansky ME;Brown JW;Rajamäki ML;Valkonen JP;Kalinina NO
核仁是一个动态的亚核体，在核糖体亚基生物发生、介导细胞应激反应和调节细胞生长中发挥作用。越来越多的报告表明，与动物病毒的蛋白质类似，许多植物病毒蛋白质定位于核仁中，使宿主核仁蛋白质偏离其天然功能，从而在病毒感染周期中发挥新的作用。本章将重点介绍植物病毒如何招募核仁功能以促进病毒翻译和复制、病毒运动和病毒特异性核糖核蛋白（RNP）颗粒的组装以及抵消植物宿主防御反应的研究。植物病毒还提供了一种有价值的工具，可以帮助我们对新的核仁功能和过程获得新的见解。研究植物病毒和核仁之间的相互作用将有助于设计控制植物病毒感染的新策略。
The nucleolus is a dynamic subnuclear body with roles in ribosome subunit biogenesis, mediation of cell-stress responses, and regulation of cell growth. An increasing number of reports reveal that similar to the proteins of animal viruses, many plant virus proteins localize in the nucleolus to divert host nucleolar proteins from their natural functions in order to exert novel role(s) in the virus infection cycle. This chapter will highlight studies showing how plant viruses recruit nucleolar functions to facilitate virus translation and replication, virus movement and assembly of virus-specific ribonucleoprotein (RNP) particles, and to counteract plant host defense responses. Plant viruses also provide a valuable tool to gain new insights into novel nucleolar functions and processes. Investigating the interactions between plant viruses and the nucleolus will facilitate the design of novel strategies to control plant virus infections.