Perceived stress predicts altered reward and loss feedback processing in medial prefrontal cortex.
Perceived stress predicts altered reward and loss feedback processing in medial prefrontal cortex.
复制标题
DOI：
10.3389/fnhum.2013.00180
复制
发表时间：
2013
影响因子：
2.9
通讯作者：
Zald DH
中科院分区：
文献类型：
--
作者：
Treadway MT;Buckholtz JW;Zald DH
压力是精神病理学发展的重要风险因素，特别是与奖励处理相关的症状。重要的是，个体在如何感知和科普压力事件方面表现出明显的差异，这种差异与压力暴露后出现精神症状的风险密切相关。然而，关于神经结构仍然存在许多问题，这些神经结构是受试者对压力源感知差异的基础。使用功能性磁共振成像（fMRI）在货币激励延迟（MID）范式，我们研究了自我报告的感知压力水平对神经活动的影响，在奖励预期和反馈的健康个体的样本。我们发现，受试者报告更多的不可控制的和压倒性的压力显示迟钝的神经反应，在内侧前额叶皮层（mPFC）的反馈有关的金钱收益以及金钱损失。这与临床前模型相一致，该模型暗示mPFC是不可控制的压力源的有害影响的关键脆弱部位。我们的数据有助于将这些发现转化为人类，并阐明一些神经机制，这些机制可能是与压力相关的风险，从而发展出与奖励相关的精神症状。
Stress is a significant risk factor for the development of psychopathology, particularly symptoms related to reward processing. Importantly, individuals display marked variation in how they perceive and cope with stressful events, and such differences are strongly linked to risk for developing psychiatric symptoms following stress exposure. However, many questions remain regarding the neural architecture that underlies inter-subject variability in perceptions of stressors. Using functional magnetic resonance imaging (fMRI) during a Monetary Incentive Delay (MID) paradigm, we examined the effects of self-reported perceived stress levels on neural activity during reward anticipation and feedback in a sample of healthy individuals. We found that subjects reporting more uncontrollable and overwhelming stressors displayed blunted neural responses in medial prefrontal cortex (mPFC) following feedback related to monetary gains as well monetary losses. This is consistent with preclinical models that implicate the mPFC as a key site of vulnerability to the noxious effects of uncontrollable stressors. Our data help translate these findings to humans, and elucidate some of the neural mechanisms that may underlie stress-linked risk for developing reward-related psychiatric symptoms.
登录
查看更多内容
影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
影响因子：
34.7
作者：
Arnsten, Amy F. T.
通讯作者：
Arnsten, Amy F. T.
影响因子：
25
作者：
Buckholtz, Joshua W.;Treadway, Michael T.;Cowan, Ronald L.;Woodward, Neil D.;Benning, Stephen D.;Li, Rui;Ansari, M. Sib;Baldwin, Ronald M.;Schwartzman, Ashley N.;Shelby, Evan S.;Smith, Clarence E.;Cole, David;Kessler, Robert M.;Zald, David H.
通讯作者：
Zald, David H.
影响因子：
5.3
作者：
Cerqueira, Joao J.;Mailliet, Francois;Sousa, Nuno
通讯作者：
Sousa, Nuno
影响因子：
7.6
作者：
Bland, ST;Hargrave, D;Maier, SF
通讯作者：
Maier, SF