Motor Performance is Impaired Following Vestibular Stimulation in Ageing Mice.
Motor Performance is Impaired Following Vestibular Stimulation in Ageing Mice.
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DOI：
10.3389/fnagi.2016.00012
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发表时间：
2016
影响因子：
4.8
通讯作者：
Camp AJ
中科院分区：
文献类型：
--
作者：
Tung VW;Burton TJ;Quail SL;Mathews MA;Camp AJ
在静态和动态运动中，保持平衡和姿势平衡对于防止福尔斯跌倒非常重要，尤其是对于老年人。虽然我们的平衡感受到前庭，本体感受和视觉信息的影响，但本研究主要关注前庭成分及其对平衡的年龄相关影响。使用标准（例如握力和旋转棒）和新开发的行为测试（包括平衡木和具有前庭刺激的行走轨迹测试）的组合测试1、5-6、8-9和27-28个月龄的C57 Bl/6 J小鼠。在目前的研究中，我们证实了随着年龄的增长，前肢握力和粗大运动协调性下降。我们还表明，前庭刺激的低频（2-3赫兹）和持续时间可以导致年龄依赖性的变化平衡木的性能，这是显而易见的延迟增加，开始走在梁上，以及从梁后脚滑（FS）的次数。此外，接受连续4周跑步轮的老年小鼠（27-28个月）在重新测试时没有改善。还测试了1、10、13和27-28个月大的小鼠由于前庭刺激而导致的行走轨迹的变化。虽然在轨迹变化和年龄之间没有观察到线性关系，但1个月大的小鼠受到的影响远小于10、13和27-28个月大的小鼠。结论：这项研究证实了握力和粗大运动协调性存在年龄相关的下降。我们还证明了年龄依赖性的变化，精细的运动能力作为一个低频率和持续时间的前庭刺激的结果。这些变化表明，虽然在所有测试年龄段中执行平衡木任务的能力保持不变，但观察到任务表现的行为变化。
Balance and maintaining postural equilibrium are important during stationary and dynamic movements to prevent falls, particularly in older adults. While our sense of balance is influenced by vestibular, proprioceptive, and visual information, this study focuses primarily on the vestibular component and its age-related effects on balance. C57Bl/6J mice of ages 1, 5–6, 8–9 and 27–28 months were tested using a combination of standard (such as grip strength and rotarod) and newly-developed behavioral tests (including balance beam and walking trajectory tests with a vestibular stimulus). In the current study, we confirm a decline in fore-limb grip strength and gross motor coordination as age increases. We also show that a vestibular stimulus of low frequency (2–3 Hz) and duration can lead to age-dependent changes in balance beam performance, which was evident by increases in latency to begin walking on the beam as well as the number of times hind-feet slip (FS) from the beam. Furthermore, aged mice (27–28 months) that received continuous access to a running wheel for 4 weeks did not improve when retested. Mice of ages 1, 10, 13 and 27–28 months were also tested for changes in walking trajectory as a result of the vestibular stimulus. While no linear relationship was observed between the changes in trajectory and age, 1-month-old mice were considerably less affected than mice of ages 10, 13 and 27–28 months. Conclusion: this study confirms there are age-related declines in grip strength and gross motor coordination. We also demonstrate age-dependent changes to finer motor abilities as a result of a low frequency and duration vestibular stimulus. These changes showed that while the ability to perform the balance beam task remained intact across all ages tested, behavioral changes in task performance were observed.