Dual-ratiometric magnetic resonance tunable nanoprobe with acidic-microenvironment-responsive property to enhance the visualization of early tumor pathological changes
Dual-ratiometric magnetic resonance tunable nanoprobe with acidic-microenvironment-responsive property to enhance the visualization of early tumor pathological changes
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DOI：
10.1007/s12274-023-5679-x
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发表时间：
2023-04
期刊：
影响因子：
9.9
通讯作者：
Rong Cao;Ning Tang;Yi Zhu;Annie Chen;Yumeng Li;Renbin Ge;Yuan Li;Zhongyi Huang;Jiajing Guo;Jiali Deng;Hongwei Lu;Ziwei Lu;Helen Forgham;T. Davis;Ruirui Qiao;Zhongling Wang
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作者：
Rong Cao;Ning Tang;Yi Zhu;Annie Chen;Yumeng Li;Renbin Ge;Yuan Li;Zhongyi Huang;Jiajing Guo;Jiali Deng;Hongwei Lu;Ziwei Lu;Helen Forgham;T. Davis;Ruirui Qiao;Zhongling Wang
微环境响应性纳米探针的发展在磁共振成像（MRI）中显示出巨大的前景，具有显着提高的特异性和良好的生物相容性的优点。然而，响应探针的临床应用受到缺乏早期分子诊断和可视化肿瘤进展中代谢重编程的微环境的生物敏感性的阻碍。在这里，我们报告了一种双比率磁共振可调（DMRT）纳米探针，该探针是通过交联不同比例的转铁蛋白螯合钆和超顺磁性纳米颗粒来设计的，并与pH响应性生物相容性聚合物复合。这种可双重激活的纳米探针能够实现pH依赖性肿瘤微环境的可视化，在体外和体内提供出色的定量病理生理信息。当与双对比增强三重减影成像技术（DETSI）结合使用时，这种智能纳米探针可以保证早期疾病的诊断。我们设想，这种新型的集成纳米平台将为早期疾病检测和分期以及微环境可视化和疾病进展监测的稳健DMRT纳米探针的临床翻译提供新的范例。
The development of microenvironment-responsive nanoprobes has shown great promise for use in magnetic resonance imaging (MRI), with the advantage of significantly improved specificity and good biocompatibility. However, the clinical application of responsive probes is hampered by a lack of biological sensitivity for early molecular diagnostics and visualizing microenvionment of metabolism reprogramming in tumor progression. Here, we report on a dual-ratiometric magnetic resonance tunable (DMRT) nanoprobe designed by crosslinking different ratios of transferrin chelating gadolinium and superparamagnetic nanoparticles, complexed to a pH responsive biocompatible polymer. This dually activatable nanoprobe enables pH-dependent tumor microenvironment visualization, providing exceptional quantitative pathophysiological informationin vitroandin vivo. When used in combination with dual-contrast enhancement triple subtraction imaging technique (DETSI), this smart nanoprobe guarantees the diagnosis of early-stage diseases. We envisage that this novel integrated nanoplatform will provide a new paradigm for the clinical translation of robust DMRT nanoprobes for early disease detection and staging, as well as microenvironment visualization and disease progression monitoring.