Pressor Responses to Noxious Stimuli in Hypertensive Patients: Effects of Guanethidine Sulfate and Alpha Methyldopa
Pressor Responses to Noxious Stimuli in Hypertensive Patients: Effects of Guanethidine Sulfate and Alpha Methyldopa
复制标题
高血压患者对有害刺激的升压反应：硫酸胍乙啶和α-甲基多巴的作用
作者：
A. P. Shapiro;E. Krifcher
高血压患者接受治疗剂量的硫酸金刚乙胺或α-甲基多巴治疗后，对几种标准化刺激的升压和脉率反应被测定。尽管这两种化合物的作用方式不同，但都显示出功能上的交感神经溶解作用。这两种药物在直立姿势下比仰卧时产生更大的血压下降，并削弱了对冷加压测试的升压反应。然而，静脉注射血管紧张素的升压反应性持续存在。对心理生理刺激的反应减弱。讨论了这些发现对治疗和了解升压反应的生理机制的意义。
The pressor and pulse rate responses to several standardized stimuli were determined in hypertensive patients receiving guanethidine sulfate or alpha methyldopa in therapeutic doses. Despite differences between the two compounds in their mode of action, both demonstrated functionally sympatholytic effects. Both drugs produced a greater blood pressure fall in the erect posture than in the supine and impaired the pressor response to the cold pressor test. The pressor reactivity to intravenous angiotensin, however, persisted. Responses to psychophysiologic stimuli were decreased. The implications of these findings for both therapy and for understanding of physiologic mechanisms of pressor reactivity are discussed.