Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole
Design, synthesis and cytotoxic activities of novel hybrid compounds between dihydrobenzofuran and imidazole
复制标题
二氢苯并呋喃与咪唑新型杂化化合物的设计、合成及细胞毒活性
DOI：
10.1039/c1ob05116d
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发表时间：
2011-01-01
影响因子：
3.2
通讯作者：
Zhang, Hong-Bin
中科院分区：
文献类型：
--
作者：
Chen, Wen;Yang, Xiao-Dong;Zhang, Hong-Bin
合成了一系列新型的二氢苯并呋喃和咪唑的杂合化合物，并在体外对一组人肿瘤细胞系进行了评价。结果表明，咪唑基-1-位置与供电子的二氢苯并呋喃，和咪唑基-3-位置与萘酰基或富电子的苯甲酰甲基基团的取代，是至关重要的调节细胞毒活性。
A series of novel hybrid compounds between dihydrobenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that substitution of the imidazolyl-1-position with an electron-donating dihydrobenzofuran, and the imidazolyl-3-position with a naphthylacyl or electron-rich phenacyl group, were vital for modulating cytotoxic activity.