Effect of Pu-erh Tea on Body Fat and Lipid Profiles in Rats with Diet-induced Obesity
Effect of Pu-erh Tea on Body Fat and Lipid Profiles in Rats with Diet-induced Obesity
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DOI：
10.1002/ptr.3247
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发表时间：
2011-02-01
影响因子：
7.2
通讯作者：
Ge, Chang-Rong
中科院分区：
文献类型：
--
作者：
Cao, Zhen-Hui;Gu, Da-Hai;Ge, Chang-Rong
观察普洱茶对高脂饮食诱导的肥胖大鼠的减肥和降血脂作用。雄性SD大鼠随机分为5组，分别饲喂对照组、高脂饲料和高脂饲料+低、中、高剂量普洱茶提取物(分别为0.5g、2g和4g/kg bw/d)。普洱茶能显著降低小鼠的总体重和各种脂肪垫重量。普洱茶还能显著降低高脂诱导肥胖大鼠的血浆总胆固醇、甘油三酯浓度和低密度脂蛋白胆固醇水平，但不影响高密度脂蛋白胆固醇水平。此外，普洱茶还能显著提高高脂诱导的肥胖大鼠附睾脂肪组织中脂蛋白脂肪酶、肝脂酶和激素敏感脂肪酶的活性。实时定量逆转录-聚合酶链式反应结果分析表明，普洱茶能显著提高高脂诱导肥胖大鼠激素敏感脂肪酶的mRNA水平。这些结果表明，普洱茶可减轻高脂饲料诱导的肥胖大鼠的内脏脂肪堆积和改善高脂血症。版权所有(C)2010 John Wiley&Sons，Ltd.
The antiobesity and antihyperlipidaemic effects of pu-erh tea in rats with high fat diet (HFD)-induced obesity were investigated. Male Sprague-Dawley rats were randomly divided into five groups and fed varying diets for an 8-week period: control diet, HFD, and HFD supplemented with low, moderate or high doses of pu-erh tea extract (0.5 g, 2 g and 4 g/kg BW/day, respectively). Pu-erh tea significantly reduced the total body weight and the weight of various adipose pads. Pu-erh tea administration also significantly lowered plasma total cholesterol, triglyceride concentrations and low-density lipoprotein-cholesterol levels in rats with HFD-induced obesity, but did not affect high-density lipoprotein-cholesterol levels. Moreover, pu-erh tea significantly increased lipoprotein lipase, hepatic lipase and hormone-sensitive lipase activities in epididymal fat tissue in rats with HFD-induced obesity. Analysis of real-time reverse transcription-polymerase chain reaction results indicated that pu-erh tea significantly enhanced mRNA levels of hormone-sensitive lipase in rats with HFD-induced obesity. These results suggest that pu-erh tea attenuated visceral fat accumulation and improved hyperlipidemia in a rat model of HFD-induced obesity. Copyright (C) 2010 John Wiley & Sons, Ltd.