Cross adaption between stress and cold in rats
Cross adaption between stress and cold in rats
复制标题
大鼠应激与寒冷的交叉适应
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
T. Ohno
中科院分区：
文献类型：
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作者：
A. Kuroshima;Y. Habara;A. Uehara;K. Murazumi;T. Yahata;T. Ohno
对Wistar品系雄性成年大鼠施加3小时固定应激，每周抑制6天，持续1 ~ 8周。与对照组相比，应激大鼠在实验中体重增加较少。这些应激动物表现出较强的耐寒性，在实验期间- 5°C低温下，结肠温度在300 min内没有显著下降，而对照组的结肠温度则逐渐下降。通过去甲肾上腺素诱导的耗氧量增加来评估，应激大鼠的非寒颤产热显著增强。应激大鼠囊间棕色脂肪组织（BAT）重量增加，蛋白质含量增加，BAT线粒体堆积增多。应激大鼠血浆胰岛素、胰岛素/胰高血糖素摩尔比和甲状腺素水平降低，血浆三碘甲状腺原氨酸水平保持不变。去除肩胛间BAT导致应激大鼠的耐寒性改善和非寒战产热能力显著降低。这些结果表明，重复应激可能通过增强非寒战产热能力（至少部分是通过刺激BAT功能）诱导应激和低温之间的交叉适应。
Three-hour immobilization stress was imposed on male adult rats of Wistar strain by restraining them on a board 6 days a week for 1–8 weeks. The stressed rats showed less body weight gain during the experiment compared to the controls. These stressed animals manifested an improved cold tolerance as shown by no significant fall in colonic temperature in the cold at −5° C for 300 min during the experimental period, while the colonic temperature of the controls fell progressively. Nonshivering thermogenesis as assessed by noradrenaline-induced increase in oxygen consumption was significantly potentiated in the stressed rats. The weight and protein content of the intercapsular brown adipose tissue (BAT) increased and BAT mitochondria were more packed in the stressed rats. Plasma insulin, insulin/glucagon molar ratio and thyroxine levels were lowered in the stressed rats, while the plasma triiodothyronine level remained unchanged. Removal of interscapular BAT led to a loss of improved cold tolerance and a significant reduction of nonshivering thermogenesis in the stressed rats.These results indicate that repetitive stress may induce cross adaptation between stress and cold through an enhanced capacity of nonshivering thermogenesis mediated, at least in part, via stimulation of BAT function.
影响因子：
2.1
作者：
Shimada,SG;Stitt,JT
通讯作者：
Stitt,JT