Suppressive responses by visual food cues in postprandial activities of insular cortex as revealed by magnetoencephalography
Suppressive responses by visual food cues in postprandial activities of insular cortex as revealed by magnetoencephalography
复制标题
脑磁图显示岛叶皮层餐后活动中视觉食物线索的抑制反应
DOI：
10.1016/j.brainres.2014.04.021
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发表时间：
2014
期刊：
影响因子：
2.9
通讯作者：
Watanabe Y.
中科院分区：
文献类型：
--
作者：
Yoshikawa T;Tanaka M;Ishii A;Watanabe Y.
“Hara-Hachibu”在日语中的意思是一种主观的感觉，即我们在完全失去进食动机之前停止进食，这与热量限制（CR）类似。岛叶皮层是将感觉信息整合到进食行为决策过程中的关键平台。我们比较了岛叶皮层的反应，脑磁图（MEG）的评估，立即呈现后的食物图像在禁食条件下与那些在'原-八'条件。11名健康的右利手男性[年龄，27.2±9.6岁;体重指数，22.6±2.1 kg/m2（平均值±SD）]入组随机双交叉实验（空腹和“Hara-Hachibu”条件）。在“Hara-Hachibu”条件下进行MEG记录之前，参与者摄入的饭团数量与他们在达到饱腹感之前不久判断自己摄入的饭团数量相同。在MEG记录期间，他们观看了投射在屏幕上的食物图片。“原-八部”状态下的MEG反应强度显著低于禁食状态下的MEG反应强度（P<0.05）。在“原-八部”条件下，MEG对视觉食物刺激的反应强度与自我报告的享乐性饥饿量表的因子3（食物品尝）（r= 0.693，P =0.018）和总分（r= 0.659，P =0.027）呈正相关。这些研究结果可能有助于阐明个体CR条件下食欲表型变异的神经基础，并为维持日常生活中足够的CR制定可能的策略。
‘Hara-Hachibu’ in Japanese means a subjective sense by which we stop eating just before the motivation to eat is completely lost, a similar concept to caloric restriction (CR). Insular cortex is a critical platform which integrates sensory information into decision-making processes in eating behavior. We compared the responses of insular cortex, as assessed by magnetoencephalography (MEG), immediately after presentation of food images in the Fasting condition with those in the ‘Hara-Hachibu’ condition. Eleven healthy, right-handed males [age, 27.2±9.6 years; body mass index, 22.6±2.1 kg/m2(mean±SD)] were enrolled in a randomized, two-crossover experiment (Fasting and ‘Hara-Hachibu’ conditions). Before the MEG recordings in the ‘Hara-Hachibu’ condition, the participants consumed rice balls as much as they judged themselves to have consumed shortly before reaching satiety. During the MEG recordings, they viewed food pictures projected on a screen. The intensities of MEG responses to viewing food pictures were significantly lower in the ‘Hara-Hachibu’ condition than those in the Fasting condition (P<0.05). The intensities of the MEG responses to the visual food stimuli in the ‘Hara-Hachibu’ condition was positively associated with the factor-3 (food tasted) (r=0.693,P=0.018) and aggregated scores (r=0.659,P=0.027) of the Power of Food Scale, a self-report measure of hedonic hunger. These findings may help to elucidate the neural basis of variability of appetite phenotypes under the condition of CR among individuals, and to develop possible strategies for the maintenance of adequate CR in daily life.