The correlation between motor impairments and event-related desynchronization during motor imagery in ALS patients
The correlation between motor impairments and event-related desynchronization during motor imagery in ALS patients
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DOI：
10.1186/1471-2202-13-66
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发表时间：
2012-06-15
期刊：
影响因子：
2.4
通讯作者：
Masakado, Yoshihisa
中科院分区：
文献类型：
--
作者：
Kasahara, Takashi;Terasaki, Kentaro;Masakado, Yoshihisa
背景资料：EEG中的事件相关去极化（ERD）被认为出现在运动想象过程中，并被认为反映了运动准备的皮层处理。本研究的目的是检查ALS患者运动障碍对ERD的调节作用。ERD在手部运动想象获得8 ALS患者与各种运动障碍。ERD也从年龄匹配的11名健康对照受试者相同的运动任务。结果：ALS患者的ERD明显小于对照组，而对照组的ERD明显小于ALS组。ALS患者眼球功能与ERD呈负相关。结论：ALS患者延髓评分恶化时，ERD可能较小。上肢运动功能与ERD无相关性。
Background: The event-related desynchronization (ERD) in EEG is known to appear during motor imagery, and is thought to reflect cortical processing for motor preparation. The aim of this study is to examine the modulation of ERD with motor impairment in ALS patients. ERD during hand motor imagery was obtained from 8 ALS patients with a variety of motor impairments. ERD was also obtained from age-matched 11 healthy control subjects with the same motor task. The magnitude and frequency of ERD were compared between groups for characterization of ALS specific changes.Results: The ERD of ALS patients were significantly smaller than those of control subjects. Bulbar function and ERD were negatively correlated in ALS patients. Motor function of the upper extremities did was uncorrelated with ERD.Conclusions: ALS patients with worsened bulbar scales may show smaller ERD. Motor function of the upper extremities did was uncorrelated with ERD.