Evaluation of normal brain development by prenatal MR imaging
Evaluation of normal brain development by prenatal MR imaging
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DOI：
10.1007/s11547-007-0153-5
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发表时间：
2007-04-01
影响因子：
8.9
通讯作者：
Marini, M.
中科院分区：
文献类型：
--
作者：
Manganaro, L.;Perrone, A.;Marini, M.
目的.本研究的目的是描述正常模式的发展和成熟的胎儿大脑相对于胎龄的评估与磁共振成像（MRI），并提供一个概述的可能性的technology.Materials和方法。对56例妊娠19 ~ 37周的孕妇进行了胎儿脑MRI检查。采用半傅立叶单次激发快速自旋回波（HASTE）、真快速稳态进动（FISP）、快速低角度激发（FLASH）T1加权二维（2D）和弥散加权（DW）序列及表观弥散系数（ADC）。采用斯皮尔曼等级相关检验将生物统计学参数和大脑皮质发育面积与胎龄进行相关性分析。我们发现，当以眼外直径比表示时，生发基质/双顶径比与胎龄呈负相关，生发基质与皮质基质呈正相关（R=0.452，p=0.02）。皮质外套与生物特征参数，如双顶径和额枕径，并与胎龄。到22周时，大脑纵裂、顶枕裂和侧裂均已出现。在灰质中，平均ADC值从1.76 × 10（-3）mm（2）/s（19周）变化到0.89 × 10（-3）mm（2）/s（37周），而在白色物质中，平均ADC值从2.03 × 10（-3）mm（2）/s（19周）变化到1.25 × 10（-3）mm（2）/s（37周）。MRI提供了一个可靠的评价脑成熟在怀孕期间。
Purpose. The aim of this study was to describe the normal pattern of development and maturation of the foetal brain with respect to gestational age as assessed with magnetic resonance imaging (MRI) and to provide an overview of the possibilities of the technique.Materials and methods. Foetal cerebral MRI was performed on 56 pregnant women between 19 and 37 weeks of gestation. Half-Fourier single-shot turbo spin-echo (HASTE), true fast imaging with steady precession (FISP), T1-weighted fast low angle shot (FLASH) two-dimensional (2D) and diffusion-weighted (DW) sequences with apparent diffusion coefficient (ADC) were obtained. Biometric parameters and developmental areas of the cerebral cortex were correlated to gestational age by using the Spearman rank correlation test.Results. We found a negative correlation between the germinal matrix/biparietal diameter ratio and gestational age and a positive correlation between the germinal and cortical matrix when expressed as external intraocular diameter ratio (R=0.452, p=0.02). The cortical mantle was correlated with biometric parameters, such as the biparietal diameter and the frontooccipital diameter, and with gestational age. The interhemispheric fissure, the parietooccipital fissure and the sylvian fissure were detectable by the 22nd week. In the grey matter, the mean ADC values varied from 1.76x10(-3) mm(2)/s (at week 19) to 0.89x10(-3) mm(2)/s (at week 37), whereas in the white matter, the values varied from 2.03x10(-3) mm(2)/s (at week 19) to 1.25x10(-3) mm(2)/s (at week 37).Conclusions. MRI provides a reliable valuation of brain maturation during pregnancy.