amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge
amos, a proneural gene for Drosophila olfactory sense organs that is regulated by lozenge
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DOI：
10.1016/s0896-6273(00)80872-7
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发表时间：
2000-01-01
期刊：
影响因子：
16.2
通讯作者：
Jarman, AP
中科院分区：
文献类型：
--
作者：
Goulding, SE;zur Lage, P;Jarman, AP
在多种生物体中，早期的神经发生需要碱性螺旋-环-螺旋(BHLH)转录因子的功能。对于果蝇PNS，这些转录因子是由原神经基因(无序和无毛-鳞状复合体，AS-C)编码的。我们已经鉴定出一个神经原基因amos，它与无性激素在其bHLH域有很强的相似性。我们提出的证据表明，AMOS是嗅觉感受器所必需的，并受前置模式基因片剂的调控。在它们之间，Amos、无调性和AS-C可能解释了整个PNS的起源。
In a variety of organisms, early neurogenesis requires the function of basic-helix-loop-helix (bHLH) transcription factors. For the Drosophila PNS, such transcription factors are encoded by the proneural genes (atonal and the achaete-scute complex, AS-C). We have identified a proneural gene, amos, that has strong similarity with atonal in its bHLH domain. We present evidence that amos is required for olfactory sensilla and is regulated by the prepattern gene lozenge. Between them, amos, atonal, and the AS-C can potentially account for the origin of the entire PNS.