The effect of recombinant human interferon alpha B/D compared to interferon alpha 2b on SIV infection in rhesus macaques.
The effect of recombinant human interferon alpha B/D compared to interferon alpha 2b on SIV infection in rhesus macaques.
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DOI：
10.1016/0166-3542(95)00955-8
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发表时间：
1996-08-01
影响因子：
7.6
通讯作者：
Heeney, JL
中科院分区：
文献类型：
--
作者：
Schellekens, H;Niphuis, H;Heeney, JL
采用猴免疫缺陷病毒（SIV）感染恒河猴的模型，评价两种剂量的重组人干扰素α（Hu IFN-α 2 B和Hu IFN-α B/D）的作用。感染前1天开始给药，感染后持续90天。两种干扰素在治疗期间均抑制SIV抗原血症。治疗后，监测动物4年的疾病进展率。IFN均未延长无症状期或生存期。
The model of simian immunodeficiency virus (SIV) infection in rhesus macaques was used to evaluate the effects of recombinant human interferon alpha, Hu IFN-alpha 2b and Hu IFN-alpha B/D, at two doses. Administration began 1 day prior to infection and was continued for 90 days postinfection. Both interferons suppressed SIV antigenemia during the treatment period. Following treatment animals were monitored for 4 years for rate of disease progression. Neither IFN prolonged the asymptomatic period or survival.