The role of cortisol in the association between prenatal air pollution and fetal growth: A prospective cohort study
The role of cortisol in the association between prenatal air pollution and fetal growth: A prospective cohort study
复制标题
皮质醇在产前空气污染与胎儿生长之间的关系中的作用：一项前瞻性队列研究
DOI：
10.1016/j.envres.2022.113250
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发表时间：
2022-04-16
影响因子：
8.3
通讯作者：
Zhu, Peng
中科院分区：
文献类型：
--
作者：
Li, Lei;Yin, Wanjun;Zhu, Peng
产前空气污染物暴露与胎儿生长受损有关。然而，其特殊的脆弱性窗口和生物学机制仍不清楚。从2015年到2020年进行了一项前瞻性出生队列研究，包括7419对母婴对，以确定临界暴露窗口，并检查皮质醇是否介导空气污染物暴露与胎儿生长之间的关系。大气污染物PM2.5、PM10、SO2和CO的数据来自合肥市生态环境局。收集胎儿超声测量和出生大小的数据。母亲和脐带血样本用于测量皮质醇。产前空气污染物（PM2.5，PM10，SO2和CO）暴露，特别是在前三个月，与从怀孕后期到出生的胎儿尺寸减小有关。PM2.5的IQR增加（β = 0.082，95%CI：0.029，0.135），PM10（β = 0.086，95%CI：0.036，0.136），SO2（β = 0.086，95%CI：0.028，0.144）和CO（β = 0.063，95%CI：0.017，0.109）妊娠早期暴露与较高的脐带血皮质醇水平相关。显着的关系，观察到在第一个三个月的空气污染物暴露和增加脐带血皮质醇水平的比例。暴露于高水平脐带血皮质醇显著降低了出生体重（β =-0.17，95% CI：-0.23，-0.10）、身长（β =-0.09，95% CI：-0.16，-0.03）和头围（β =-0.33，95% CI：-0.42，-0.25）的Z评分。中介作用分析显示，新生儿脐血皮质醇介导的孕早期大气污染物暴露与新生儿各项指标的关联为20.62%。这些结果表明，在怀孕期间的空气污染物暴露可以通过增加胎儿皮质醇水平，由于胎盘屏障损伤，降低胎儿的生长，与暴露的关键窗口发生在第一孕期。
Prenatal air pollutant exposure has been linked to impaired fetal growth. However, its special vulnerability windows and biological mechanisms remain unclear. A prospective birth cohort study including 7419 mothernewborn pairs was conducted from 2015 to 2020 to determine critical exposure windows and examine whether cortisol mediates the relationship between air pollutant exposure and fetal growth. Air pollutant data for PM2.5, PM10, SO2, and CO were obtained from the Hefei City Ecology and Environment Bureau. Data on fetal ultrasound measurements and birth size were collected. Maternal and cord blood samples were used for measuring cortisol. Prenatal air pollutant (PM2.5, PM10, SO2, and CO) exposure, particularly in the first trimester, was associated with reduced fetal size from later pregnancy to birth. An IQR increase in PM2.5 (beta = 0.082, 95%CI: 0.029, 0.135), PM10 (beta = 0.086, 95%CI: 0.036, 0.136), SO2 (beta = 0.086, 95%CI: 0.028, 0.144), and CO (beta = 0.063, 95%CI: 0.017, 0.109) exposure in the first trimester was associated with higher cord blood cortisol levels. Significant relationships were observed between air pollutant exposure in the first trimester and increased ratio of cord to maternal blood cortisol levels. Exposure to high levels of cord blood cortisol significantly reduced the Z scores of birth weight (beta = -0.17, 95%CI: -0.23, -0.10), length (beta = -0.09, 95%CI: -0.16, -0.03), and head circumference (beta = -0.33, 95%CI: -0.42, -0.25). Mediation analysis showed that the association of air pollutant exposure in the first trimester with neonatal parameters mediated by cord blood cortisol was 20.62%. These results indicated that air pollutant exposure during pregnancy could reduce fetal growth by the increased fetal cortisol levels due to placental barrier impairment, with the critical window of exposure occurring in the first trimester.