Histamine infused into basolateral amygdala enhances memory consolidation of inhibitory avoidance
Histamine infused into basolateral amygdala enhances memory consolidation of inhibitory avoidance
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DOI：
10.1017/s1461145712001514
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发表时间：
2013-08-01
影响因子：
4.8
通讯作者：
Izquierdo, Ivan
中科院分区：
文献类型：
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作者：
Benetti, Fernando;Izquierdo, Ivan
基底外侧杏仁核（BLA）在厌恶记忆巩固中的作用已经得到了很好的证实。在这里，我们调查的参与组胺能系统在BLA对这个变量。大鼠在BLA长期植入双侧插管，恢复后进行一次性降压抑制回避任务训练。训练后立即通过插管输注单独或组合的组胺能化合物。在训练后24小时进行的测试中评估记忆。训练后组胺（1-10 nmol; 0.5 μ l/侧）增强巩固，组胺H-3受体拮抗剂硫代哌丁胺（50 nmol; 0.5 μ l/侧）损害记忆巩固。组胺N-甲基转移酶抑制剂SKF-91844（50 nmol; 0.5 μ l/侧）以及H-3受体激动剂imetit（10 nmol; 0.5 μ l/侧）也具有这种作用。组胺的促记忆作用不受H-1受体拮抗剂吡拉明（50 nmol; 0.5 μ l/侧）的影响。H-1受体激动剂吡啶乙胺（10 nmol; 0.5 μ l/侧）、H-2受体激动剂二甲双胍（10 nmol; 0.5 μ l/侧）和H-2受体拮抗剂雷尼替丁（50 nmol; 0.5 μ l/侧）无效。注入BLA的组胺能化合物对旷场或高架十字迷宫行为没有影响。数据表明，组胺诱导大鼠的剂量依赖性记忆效应，并表明这反映了内源性组胺的作用，在BLA介导的H-3受体。
The role of the basolateral amygdala (BLA) in the consolidation of aversive memory is well established. Here we investigate the involvement of the histaminergic system in BLA on this variable. Rats were chronically implanted with bilateral cannulae in the BLA and after recovery were trained in a one-trial step-down inhibitory avoidance task. Immediately after training histaminergic compounds either alone or in combination were infused through the cannulae. Memory was assessed in test sessions carried out 24 h after the training session. Post-training histamine (1-10 nmol; 0.5 mu l/side) enhanced consolidation and the histamine H-3 receptor antagonist thioperamide (50 nmol; 0.5 mu l/side) impaired memory consolidation. The effect was shared by the histamine N-methyltransferase inhibitor SKF-91844 (50 nmol; 0.5 mu l/side) as well as by the H-3 receptor agonist imetit (10 nmol; 0.5 mu l/side). The promnesic action of histamine was unaffected by the H-1 receptor antagonist pyrilamine (50 nmol; 0.5 mu l/side). The H-1 receptor agonist pyridylethylamine (10 nmol; 0.5 mu l/side), the H-2 agonist dimaprit (10 nmol; 0.5 mu l/side) and the H-2 antagonist ranitidine (50 nmol; 0.5 mu l/side) were ineffective. Histaminergic compounds infused into the BLA had no effect on open-field or elevated plus-maze behaviour. The data show that histamine induces a dose-dependent mnemonic effect in rats and indicate that this reflects a role of endogenous histamine in the BLA mediated by H-3 receptors.